1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy in experimental filariasis

Amita Shukla-Dave; Nigar Fatma; Raja Roy; S. Srivastava; R. K. Chatterjee; V. Govindaraju; A. Kasi Viswanathan; P. Raghunathan

doi:10.1016/S0730-725X(97)00180-X

¹H Magnetic resonance imaging and ³¹P magnetic resonance spectroscopy in experimental filariasis

Amita Shukla-Dave, Nigar Fatma, Raja Roy, S. Srivastava, R. K. Chatterjee, V. Govindaraju, A. Kasi Viswanathan, P. Raghunathan

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

¹H Magnetic resonance imaging and ³¹P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T₂-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid nests in the cervical region. ³¹P MRS of normal and infected hosts, localized over the same region of interest, show seven major peaks corresponding to phosphomonoesters (including glucose-6- phosphate, fructose-6-phosphate, fructose-1-6-diphosphate, phosphorylcholine, and adenine monophosphate or AMP), inorganic phosphate, glycerophosphorylcholine, phosphoenolpyruvate, phosphocreatine and nucleoside di- and tri-phosphates. Concentrations of phosphomonoesters (PMEs) are higher in the normal rodent compared with the infected ones; In vivo ³¹P MRS provides a non-invasive assessment of tissue bioenergetics and phospholipid metabolism.

Original language	English (US)
Pages (from-to)	1193-1198
Number of pages	6
Journal	Magnetic Resonance Imaging
Volume	15
Issue number	10
DOIs	https://doi.org/10.1016/S0730-725X(97)00180-X
State	Published - Jan 1 1997
Externally published	Yes

Keywords

H Magnetic resonance imaging
P Magnetic resonance spectroscopy
Acanthocheilonema viteae
Filariasis
Mastomys coucha
Phosphorus metabolism

ASJC Scopus subject areas

Biophysics
Clinical Biochemistry
Structural Biology
Radiology Nuclear Medicine and imaging
Condensed Matter Physics

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10.1016/S0730-725X(97)00180-X

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Shukla-Dave, A., Fatma, N., Roy, R., Srivastava, S., Chatterjee, R. K., Govindaraju, V., Viswanathan, A. K., & Raghunathan, P. (1997). ¹H Magnetic resonance imaging and ³¹P magnetic resonance spectroscopy in experimental filariasis. Magnetic Resonance Imaging, 15(10), 1193-1198. https://doi.org/10.1016/S0730-725X(97)00180-X

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title = "1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy in experimental filariasis",

abstract = " 1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid nests in the cervical region. 31P MRS of normal and infected hosts, localized over the same region of interest, show seven major peaks corresponding to phosphomonoesters (including glucose-6- phosphate, fructose-6-phosphate, fructose-1-6-diphosphate, phosphorylcholine, and adenine monophosphate or AMP), inorganic phosphate, glycerophosphorylcholine, phosphoenolpyruvate, phosphocreatine and nucleoside di- and tri-phosphates. Concentrations of phosphomonoesters (PMEs) are higher in the normal rodent compared with the infected ones; In vivo 31P MRS provides a non-invasive assessment of tissue bioenergetics and phospholipid metabolism.",

keywords = "H Magnetic resonance imaging, P Magnetic resonance spectroscopy, Acanthocheilonema viteae, Filariasis, Mastomys coucha, Phosphorus metabolism",

author = "Amita Shukla-Dave and Nigar Fatma and Raja Roy and S. Srivastava and Chatterjee, {R. K.} and V. Govindaraju and Viswanathan, {A. Kasi} and P. Raghunathan",

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AU - Shukla-Dave, Amita

AU - Fatma, Nigar

AU - Roy, Raja

AU - Srivastava, S.

AU - Chatterjee, R. K.

AU - Govindaraju, V.

AU - Viswanathan, A. Kasi

AU - Raghunathan, P.

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N2 - 1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid nests in the cervical region. 31P MRS of normal and infected hosts, localized over the same region of interest, show seven major peaks corresponding to phosphomonoesters (including glucose-6- phosphate, fructose-6-phosphate, fructose-1-6-diphosphate, phosphorylcholine, and adenine monophosphate or AMP), inorganic phosphate, glycerophosphorylcholine, phosphoenolpyruvate, phosphocreatine and nucleoside di- and tri-phosphates. Concentrations of phosphomonoesters (PMEs) are higher in the normal rodent compared with the infected ones; In vivo 31P MRS provides a non-invasive assessment of tissue bioenergetics and phospholipid metabolism.

AB - 1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid nests in the cervical region. 31P MRS of normal and infected hosts, localized over the same region of interest, show seven major peaks corresponding to phosphomonoesters (including glucose-6- phosphate, fructose-6-phosphate, fructose-1-6-diphosphate, phosphorylcholine, and adenine monophosphate or AMP), inorganic phosphate, glycerophosphorylcholine, phosphoenolpyruvate, phosphocreatine and nucleoside di- and tri-phosphates. Concentrations of phosphomonoesters (PMEs) are higher in the normal rodent compared with the infected ones; In vivo 31P MRS provides a non-invasive assessment of tissue bioenergetics and phospholipid metabolism.

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KW - Phosphorus metabolism

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