TY - JOUR
T1 - 1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy in experimental filariasis
AU - Shukla-Dave, Amita
AU - Fatma, Nigar
AU - Roy, Raja
AU - Srivastava, S.
AU - Chatterjee, R. K.
AU - Govindaraju, V.
AU - Viswanathan, A. Kasi
AU - Raghunathan, P.
N1 - Funding Information:
Acknowledgmenfs-Financial assistance in the form of a fellowship to A.S.D. and N.F. from the Council of Scientific & Industrial Research, New Delhi, India is gratefully acknowledged.
PY - 1997
Y1 - 1997
N2 -
1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid nests in the cervical region. 31P MRS of normal and infected hosts, localized over the same region of interest, show seven major peaks corresponding to phosphomonoesters (including glucose-6- phosphate, fructose-6-phosphate, fructose-1-6-diphosphate, phosphorylcholine, and adenine monophosphate or AMP), inorganic phosphate, glycerophosphorylcholine, phosphoenolpyruvate, phosphocreatine and nucleoside di- and tri-phosphates. Concentrations of phosphomonoesters (PMEs) are higher in the normal rodent compared with the infected ones; In vivo 31P MRS provides a non-invasive assessment of tissue bioenergetics and phospholipid metabolism.
AB -
1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid nests in the cervical region. 31P MRS of normal and infected hosts, localized over the same region of interest, show seven major peaks corresponding to phosphomonoesters (including glucose-6- phosphate, fructose-6-phosphate, fructose-1-6-diphosphate, phosphorylcholine, and adenine monophosphate or AMP), inorganic phosphate, glycerophosphorylcholine, phosphoenolpyruvate, phosphocreatine and nucleoside di- and tri-phosphates. Concentrations of phosphomonoesters (PMEs) are higher in the normal rodent compared with the infected ones; In vivo 31P MRS provides a non-invasive assessment of tissue bioenergetics and phospholipid metabolism.
KW - H Magnetic resonance imaging
KW - P Magnetic resonance spectroscopy
KW - Acanthocheilonema viteae
KW - Filariasis
KW - Mastomys coucha
KW - Phosphorus metabolism
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U2 - 10.1016/S0730-725X(97)00180-X
DO - 10.1016/S0730-725X(97)00180-X
M3 - Article
C2 - 9408140
AN - SCOPUS:0030608933
VL - 15
SP - 1193
EP - 1198
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 10
ER -