1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy in experimental filariasis

Amita Shukla-Dave, Nigar Fatma, Raja Roy, S. Srivastava, R. K. Chatterjee, V. Govindaraju, A. Kasi Viswanathan, P. Raghunathan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid nests in the cervical region. 31P MRS of normal and infected hosts, localized over the same region of interest, show seven major peaks corresponding to phosphomonoesters (including glucose-6- phosphate, fructose-6-phosphate, fructose-1-6-diphosphate, phosphorylcholine, and adenine monophosphate or AMP), inorganic phosphate, glycerophosphorylcholine, phosphoenolpyruvate, phosphocreatine and nucleoside di- and tri-phosphates. Concentrations of phosphomonoesters (PMEs) are higher in the normal rodent compared with the infected ones; In vivo 31P MRS provides a non-invasive assessment of tissue bioenergetics and phospholipid metabolism.

Original languageEnglish (US)
Pages (from-to)1193-1198
Number of pages6
JournalMagnetic Resonance Imaging
Issue number10
StatePublished - 1997
Externally publishedYes


  • H Magnetic resonance imaging
  • P Magnetic resonance spectroscopy
  • Acanthocheilonema viteae
  • Filariasis
  • Mastomys coucha
  • Phosphorus metabolism

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics


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