Sudden Cardiac Death Risk Stratification

Marc W. Deyell, Andrew D. Krahn, Jeffrey Goldberger

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Arrhythmic sudden cardiac death (SCD) may be caused by ventricular tachycardia/fibrillation or pulseless electric activity/asystole. Effective risk stratification to identify patients at risk of arrhythmic SCD is essential for targeting our healthcare and research resources to tackle this important public health issue. Although our understanding of SCD because of pulseless electric activity/asystole is growing, the overwhelming majority of research in risk stratification has focused on SCD-ventricular tachycardia/ventricular fibrillation. This review focuses on existing and novel risk stratification tools for SCD-ventricular tachycardia/ventricular fibrillation. For patients with left ventricular dysfunction or myocardial infarction, advances in imaging, measures of cardiac autonomic function, and measures of repolarization have shown considerable promise in refining risk. Yet the majority of SCD-ventricular tachycardia/ventricular fibrillation occurs in patients without known cardiac disease. Biomarkers and novel imaging techniques may provide further risk stratification in the general population beyond traditional risk stratification for coronary artery disease alone. Despite these advances, significant challenges in risk stratification remain that must be overcome before a meaningful impact on SCD can be realized.

Original languageEnglish (US)
Pages (from-to)1907-1918
Number of pages12
JournalCirculation Research
Volume116
Issue number12
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Sudden Cardiac Death
Ventricular Fibrillation
Ventricular Tachycardia
Heart Arrest
Health Services Research
Left Ventricular Dysfunction
Coronary Artery Disease
Heart Diseases
Public Health
Biomarkers
Myocardial Infarction
Research
Population

Keywords

  • death, sudden, cardiac
  • risk assessment
  • tachycardia, ventricular

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Sudden Cardiac Death Risk Stratification. / Deyell, Marc W.; Krahn, Andrew D.; Goldberger, Jeffrey.

In: Circulation Research, Vol. 116, No. 12, 01.01.2015, p. 1907-1918.

Research output: Contribution to journalArticle

Deyell, Marc W. ; Krahn, Andrew D. ; Goldberger, Jeffrey. / Sudden Cardiac Death Risk Stratification. In: Circulation Research. 2015 ; Vol. 116, No. 12. pp. 1907-1918.
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