Abstract
An 18-yr-old woman with cystic fibrosis who received a double-lung transplant developed a severe episode of acute lung rejection. Bronchoalveolar lavage and transbronchial biopsy were used to establish the diagnosis. The rejection was refractory to administration of high-dose pulse steroids. OKT3 therapy was successfully used to reverse this episode. This is the first case report of a steroid-resistant double-lung allograft rejection successfully treated with OKT3.
| Original language | English |
|---|---|
| Pages (from-to) | 224-226 |
| Number of pages | 3 |
| Journal | American Review of Respiratory Disease |
| Volume | 144 |
| Issue number | 1 |
| State | Published - Jan 1 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3. / Shennib, H.; Mercado, M.; Nguyen, Dao; Ernst, P.; Lebel, F.; O'Donovan, M.; Fraser, R.; Tchervenkov, C.; Morin, J. F.; Mulder, D.
In: American Review of Respiratory Disease, Vol. 144, No. 1, 01.01.1991, p. 224-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3
AU - Shennib, H.
AU - Mercado, M.
AU - Nguyen, Dao
AU - Ernst, P.
AU - Lebel, F.
AU - O'Donovan, M.
AU - Fraser, R.
AU - Tchervenkov, C.
AU - Morin, J. F.
AU - Mulder, D.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - An 18-yr-old woman with cystic fibrosis who received a double-lung transplant developed a severe episode of acute lung rejection. Bronchoalveolar lavage and transbronchial biopsy were used to establish the diagnosis. The rejection was refractory to administration of high-dose pulse steroids. OKT3 therapy was successfully used to reverse this episode. This is the first case report of a steroid-resistant double-lung allograft rejection successfully treated with OKT3.
AB - An 18-yr-old woman with cystic fibrosis who received a double-lung transplant developed a severe episode of acute lung rejection. Bronchoalveolar lavage and transbronchial biopsy were used to establish the diagnosis. The rejection was refractory to administration of high-dose pulse steroids. OKT3 therapy was successfully used to reverse this episode. This is the first case report of a steroid-resistant double-lung allograft rejection successfully treated with OKT3.
UR - http://www.scopus.com/inward/record.url?scp=0025896104&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025896104&partnerID=8YFLogxK
M3 - Article
VL - 144
SP - 224
EP - 226
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 1
ER -