Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3

H. Shennib, M. Mercado, Dao Nguyen, P. Ernst, F. Lebel, M. O'Donovan, R. Fraser, C. Tchervenkov, J. F. Morin, D. Mulder

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An 18-yr-old woman with cystic fibrosis who received a double-lung transplant developed a severe episode of acute lung rejection. Bronchoalveolar lavage and transbronchial biopsy were used to establish the diagnosis. The rejection was refractory to administration of high-dose pulse steroids. OKT3 therapy was successfully used to reverse this episode. This is the first case report of a steroid-resistant double-lung allograft rejection successfully treated with OKT3.

Original languageEnglish
Pages (from-to)224-226
Number of pages3
JournalAmerican Review of Respiratory Disease
Volume144
Issue number1
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Muromonab-CD3
Allografts
Steroids
Lung
Bronchoalveolar Lavage
Cystic Fibrosis
Therapeutics
Transplants
Biopsy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Shennib, H., Mercado, M., Nguyen, D., Ernst, P., Lebel, F., O'Donovan, M., ... Mulder, D. (1991). Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3. American Review of Respiratory Disease, 144(1), 224-226.

Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3. / Shennib, H.; Mercado, M.; Nguyen, Dao; Ernst, P.; Lebel, F.; O'Donovan, M.; Fraser, R.; Tchervenkov, C.; Morin, J. F.; Mulder, D.

In: American Review of Respiratory Disease, Vol. 144, No. 1, 01.01.1991, p. 224-226.

Research output: Contribution to journalArticle

Shennib, H, Mercado, M, Nguyen, D, Ernst, P, Lebel, F, O'Donovan, M, Fraser, R, Tchervenkov, C, Morin, JF & Mulder, D 1991, 'Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3', American Review of Respiratory Disease, vol. 144, no. 1, pp. 224-226.
Shennib, H. ; Mercado, M. ; Nguyen, Dao ; Ernst, P. ; Lebel, F. ; O'Donovan, M. ; Fraser, R. ; Tchervenkov, C. ; Morin, J. F. ; Mulder, D. / Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3. In: American Review of Respiratory Disease. 1991 ; Vol. 144, No. 1. pp. 224-226.
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