Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3

H. Shennib; M. Mercado; D. Nguyen; P. Ernst; F. Lebel; M. O'Donovan; R. Fraser; C. Tchervenkov; J. F. Morin; D. Mulder

doi:10.1164/ajrccm/144.1.224

Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3

H. Shennib, M. Mercado, D. Nguyen, P. Ernst, F. Lebel, M. O'Donovan, R. Fraser, C. Tchervenkov, J. F. Morin, D. Mulder

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

An 18-yr-old woman with cystic fibrosis who received a double-lung transplant developed a severe episode of acute lung rejection. Bronchoalveolar lavage and transbronchial biopsy were used to establish the diagnosis. The rejection was refractory to administration of high-dose pulse steroids. OKT3 therapy was successfully used to reverse this episode. This is the first case report of a steroid-resistant double-lung allograft rejection successfully treated with OKT3.

Original language	English (US)
Pages (from-to)	224-226
Number of pages	3
Journal	American Review of Respiratory Disease
Volume	144
Issue number	1
DOIs	https://doi.org/10.1164/ajrccm/144.1.224
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1164/ajrccm/144.1.224

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Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3. / Shennib, H.; Mercado, M.; Nguyen, D.; Ernst, P.; Lebel, F.; O'Donovan, M.; Fraser, R.; Tchervenkov, C.; Morin, J. F.; Mulder, D.

In: American Review of Respiratory Disease, Vol. 144, No. 1, 1991, p. 224-226.

Research output: Contribution to journal › Article › peer-review

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doi = "10.1164/ajrccm/144.1.224",

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AU - Mercado, M.

AU - Nguyen, D.

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AU - Lebel, F.

AU - O'Donovan, M.

AU - Fraser, R.

AU - Tchervenkov, C.

AU - Morin, J. F.

AU - Mulder, D.

PY - 1991

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AB - An 18-yr-old woman with cystic fibrosis who received a double-lung transplant developed a severe episode of acute lung rejection. Bronchoalveolar lavage and transbronchial biopsy were used to establish the diagnosis. The rejection was refractory to administration of high-dose pulse steroids. OKT3 therapy was successfully used to reverse this episode. This is the first case report of a steroid-resistant double-lung allograft rejection successfully treated with OKT3.

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Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3

Abstract

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