Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3

H. Shennib, M. Mercado, D. Nguyen, P. Ernst, F. Lebel, M. O'Donovan, R. Fraser, C. Tchervenkov, J. F. Morin, D. Mulder

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

An 18-yr-old woman with cystic fibrosis who received a double-lung transplant developed a severe episode of acute lung rejection. Bronchoalveolar lavage and transbronchial biopsy were used to establish the diagnosis. The rejection was refractory to administration of high-dose pulse steroids. OKT3 therapy was successfully used to reverse this episode. This is the first case report of a steroid-resistant double-lung allograft rejection successfully treated with OKT3.

Original languageEnglish (US)
Pages (from-to)224-226
Number of pages3
JournalAmerican Review of Respiratory Disease
Volume144
Issue number1
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Shennib, H., Mercado, M., Nguyen, D., Ernst, P., Lebel, F., O'Donovan, M., Fraser, R., Tchervenkov, C., Morin, J. F., & Mulder, D. (1991). Successful treatment of steroid-resistant double-lung allograft rejection with Orthoclone® OKT3. American Review of Respiratory Disease, 144(1), 224-226. https://doi.org/10.1164/ajrccm/144.1.224