Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients

D. Jenkins, L. DiFrancesco, A. Chaudhry, D. Morris, S. Glück, A. Jones, R. Woodman, C. B. Brown, J. Russell, D. A. Stewart

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We report three cases of post-transplant lymphoproliferative disorder (PTLD) in the context of autologous stem cell transplantation (ASCT) for multiple myeloma (MM) and non-Hodgkin's lymphoma. The first two cases received ASCT for MM, one with a CD34-selected autograft and the other with an unmanipulated autograft. Both these cases of PTLD achieved a complete response following treatment with IVIG, gancyclovir, solumedrol and interferon (IFN). The third case received ASCT with an unmanipulated autograft for relapsed angioimmunoblastic lymphoma. He also achieved a complete response but only after rituximab was added to IVIG, gancyclovir, solumedrol and IFN. None of these patients experienced a relapse of their PTLD with follow-up ranging from 1.5 to 5 years. These cases highlight the importance of considering PTLD in the differential diagnosis of lymphadenopathy and fever post ASCT. They also demonstrate the possibility of durable complete remission of post-ASCT PTLD following antiviral and immune modulating therapy.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalBone Marrow Transplantation
Volume30
Issue number5
DOIs
StatePublished - Sep 1 2002

Keywords

  • Autologous stem cell transplantation
  • Epstein-Barr virus
  • Gancyclovir
  • Interferon
  • Post-transplant lymphoproliferative disorder
  • Rituximab

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Jenkins, D., DiFrancesco, L., Chaudhry, A., Morris, D., Glück, S., Jones, A., Woodman, R., Brown, C. B., Russell, J., & Stewart, D. A. (2002). Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients. Bone Marrow Transplantation, 30(5), 321-326. https://doi.org/10.1038/sj.bmt.1703603