Abstract
We report three cases of post-transplant lymphoproliferative disorder (PTLD) in the context of autologous stem cell transplantation (ASCT) for multiple myeloma (MM) and non-Hodgkin's lymphoma. The first two cases received ASCT for MM, one with a CD34-selected autograft and the other with an unmanipulated autograft. Both these cases of PTLD achieved a complete response following treatment with IVIG, gancyclovir, solumedrol and interferon (IFN). The third case received ASCT with an unmanipulated autograft for relapsed angioimmunoblastic lymphoma. He also achieved a complete response but only after rituximab was added to IVIG, gancyclovir, solumedrol and IFN. None of these patients experienced a relapse of their PTLD with follow-up ranging from 1.5 to 5 years. These cases highlight the importance of considering PTLD in the differential diagnosis of lymphadenopathy and fever post ASCT. They also demonstrate the possibility of durable complete remission of post-ASCT PTLD following antiviral and immune modulating therapy.
Original language | English (US) |
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Pages (from-to) | 321-326 |
Number of pages | 6 |
Journal | Bone Marrow Transplantation |
Volume | 30 |
Issue number | 5 |
DOIs | |
State | Published - Sep 2002 |
Keywords
- Autologous stem cell transplantation
- Epstein-Barr virus
- Gancyclovir
- Interferon
- Post-transplant lymphoproliferative disorder
- Rituximab
ASJC Scopus subject areas
- Hematology
- Transplantation