Successful Treatment of Invasive Fungal Infection Due to Highly Resistant Aspergillus calidoustus in an Allogeneic Hematopoietic Cell Transplant Recipient

Maria A. Mendoza, Anthony Anderson, Michele I. Morris, Lazaros Lekakis, Jacques Simkins, Clara E. Prado, Octavio V. Martinez, Krishna V. Komanduri, Jose F. Camargo

Research output: Contribution to journalArticle

Abstract

Invasive aspergillosis (IA) is the most common invasive fungal infection following a hematopoietic cell transplant, with emerging cryptic species exhibiting resistance to commonly used antifungals such as azoles. These species have been increasingly found after the introduction of anti-mold prophylaxis. We report a case of a 56-year-old female with primary myelofibrosis whose allogeneic hematopoietic cell transplant was complicated by disseminated fungal infection (skin, lung) due to Aspergillus calidoustus, a cryptic specie. Treatment of Aspergillus species remains challenging as these cryptic species are usually resistant to azoles including voriconazole which is the first line of treatment of IA. Infection was successfully treated with surgical excision and combination antifungal therapy based on in vitro susceptibility and synergy testing. Therapy included isavuconazole, a drug that has been shown to be non-inferior to voriconazole in the treatment of invasive mold infections.

Original languageEnglish (US)
JournalMycopathologia
DOIs
StateAccepted/In press - Jan 1 2020

Fingerprint

Aspergillus
Transplants
azoles
aspergillosis
Azoles
Aspergillosis
infection
molds (fungi)
cells
Fungi
therapeutics
excision
Therapeutics
Primary Myelofibrosis
skin (animal)
Mycoses
disease control
Infection
lungs
case studies

Keywords

  • Antifungal susceptibility testing
  • Antifungal therapy
  • Aspergillus calidoustus
  • Aspergillus ustus
  • Cryptic species
  • Invasive aspergillosis
  • Isavuconazole

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology
  • Agronomy and Crop Science
  • veterinary (miscalleneous)

Cite this

Successful Treatment of Invasive Fungal Infection Due to Highly Resistant Aspergillus calidoustus in an Allogeneic Hematopoietic Cell Transplant Recipient. / Mendoza, Maria A.; Anderson, Anthony; Morris, Michele I.; Lekakis, Lazaros; Simkins, Jacques; Prado, Clara E.; Martinez, Octavio V.; Komanduri, Krishna V.; Camargo, Jose F.

In: Mycopathologia, 01.01.2020.

Research output: Contribution to journalArticle

Mendoza, Maria A. ; Anderson, Anthony ; Morris, Michele I. ; Lekakis, Lazaros ; Simkins, Jacques ; Prado, Clara E. ; Martinez, Octavio V. ; Komanduri, Krishna V. ; Camargo, Jose F. / Successful Treatment of Invasive Fungal Infection Due to Highly Resistant Aspergillus calidoustus in an Allogeneic Hematopoietic Cell Transplant Recipient. In: Mycopathologia. 2020.
@article{dbc7fc79ea3747a3a2a0d1460d7c2fe3,
title = "Successful Treatment of Invasive Fungal Infection Due to Highly Resistant Aspergillus calidoustus in an Allogeneic Hematopoietic Cell Transplant Recipient",
abstract = "Invasive aspergillosis (IA) is the most common invasive fungal infection following a hematopoietic cell transplant, with emerging cryptic species exhibiting resistance to commonly used antifungals such as azoles. These species have been increasingly found after the introduction of anti-mold prophylaxis. We report a case of a 56-year-old female with primary myelofibrosis whose allogeneic hematopoietic cell transplant was complicated by disseminated fungal infection (skin, lung) due to Aspergillus calidoustus, a cryptic specie. Treatment of Aspergillus species remains challenging as these cryptic species are usually resistant to azoles including voriconazole which is the first line of treatment of IA. Infection was successfully treated with surgical excision and combination antifungal therapy based on in vitro susceptibility and synergy testing. Therapy included isavuconazole, a drug that has been shown to be non-inferior to voriconazole in the treatment of invasive mold infections.",
keywords = "Antifungal susceptibility testing, Antifungal therapy, Aspergillus calidoustus, Aspergillus ustus, Cryptic species, Invasive aspergillosis, Isavuconazole",
author = "Mendoza, {Maria A.} and Anthony Anderson and Morris, {Michele I.} and Lazaros Lekakis and Jacques Simkins and Prado, {Clara E.} and Martinez, {Octavio V.} and Komanduri, {Krishna V.} and Camargo, {Jose F.}",
year = "2020",
month = "1",
day = "1",
doi = "10.1007/s11046-019-00423-x",
language = "English (US)",
journal = "Mycopathologia",
issn = "0301-486X",
publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Successful Treatment of Invasive Fungal Infection Due to Highly Resistant Aspergillus calidoustus in an Allogeneic Hematopoietic Cell Transplant Recipient

AU - Mendoza, Maria A.

AU - Anderson, Anthony

AU - Morris, Michele I.

AU - Lekakis, Lazaros

AU - Simkins, Jacques

AU - Prado, Clara E.

AU - Martinez, Octavio V.

AU - Komanduri, Krishna V.

AU - Camargo, Jose F.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Invasive aspergillosis (IA) is the most common invasive fungal infection following a hematopoietic cell transplant, with emerging cryptic species exhibiting resistance to commonly used antifungals such as azoles. These species have been increasingly found after the introduction of anti-mold prophylaxis. We report a case of a 56-year-old female with primary myelofibrosis whose allogeneic hematopoietic cell transplant was complicated by disseminated fungal infection (skin, lung) due to Aspergillus calidoustus, a cryptic specie. Treatment of Aspergillus species remains challenging as these cryptic species are usually resistant to azoles including voriconazole which is the first line of treatment of IA. Infection was successfully treated with surgical excision and combination antifungal therapy based on in vitro susceptibility and synergy testing. Therapy included isavuconazole, a drug that has been shown to be non-inferior to voriconazole in the treatment of invasive mold infections.

AB - Invasive aspergillosis (IA) is the most common invasive fungal infection following a hematopoietic cell transplant, with emerging cryptic species exhibiting resistance to commonly used antifungals such as azoles. These species have been increasingly found after the introduction of anti-mold prophylaxis. We report a case of a 56-year-old female with primary myelofibrosis whose allogeneic hematopoietic cell transplant was complicated by disseminated fungal infection (skin, lung) due to Aspergillus calidoustus, a cryptic specie. Treatment of Aspergillus species remains challenging as these cryptic species are usually resistant to azoles including voriconazole which is the first line of treatment of IA. Infection was successfully treated with surgical excision and combination antifungal therapy based on in vitro susceptibility and synergy testing. Therapy included isavuconazole, a drug that has been shown to be non-inferior to voriconazole in the treatment of invasive mold infections.

KW - Antifungal susceptibility testing

KW - Antifungal therapy

KW - Aspergillus calidoustus

KW - Aspergillus ustus

KW - Cryptic species

KW - Invasive aspergillosis

KW - Isavuconazole

UR - http://www.scopus.com/inward/record.url?scp=85077680646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85077680646&partnerID=8YFLogxK

U2 - 10.1007/s11046-019-00423-x

DO - 10.1007/s11046-019-00423-x

M3 - Article

AN - SCOPUS:85077680646

JO - Mycopathologia

JF - Mycopathologia

SN - 0301-486X

ER -