Successful Treatment of Disseminated Disease Due to Highly Resistant Aspergillus calidoustus with a Novel Antifungal Therapy

Jose F. Camargo, Raed Jabr, Anthony D. Anderson, Lazaros Lekakis, Meilin Diaz-Paez, Laurence M. Briski, Mohammed Raja, Michele I. Morris, Krishna V. Komanduri, Denise Pereira

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Invasive aspergillosis is the most common invasive mold infection following a hematopoietic cell transplant. Widespread use of antifungal prophylaxis has led to the increasing incidence of cryptic Aspergillus species. Aspergillus calidoustus is one of those emerging species and is notorious for multidrug resistance to antifungals. Here, we report a case of disseminated A. calidoustus infection in a hematopoietic stem cell transplant recipient who was successfully treated with combination therapy that included a novel antifungal.

Original languageEnglish (US)
Article numbere02206-21
JournalAntimicrobial agents and chemotherapy
Volume66
Issue number3 March
DOIs
StatePublished - Mar 2022

Keywords

  • APX001
  • Aspergillus calidoustus
  • hematopoietic cell transplant

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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