Abstract
Rituximab, a chimeric monoclonal anti-CD20 antibody, has shown activity in several autoimmune disorders. We describe a case of a 52 years old female who was diagnosed with idiopathic thrombocytopenic purpura and concomitant autoimmune hepatitis (AIH), both non-responsive to steroids. She was subsequently treated with rituximab, which resulted in a rapid increase in her platelet count and an unexpected normalization of her hepatic biochemical tests. Both her platelet count and her hepatic biochemical tests remained normal for over 5 months. In this case, rituximab showed an impressive clinical response for the treatment of AIH, and it may be considered as an alternative treatment in patients who do not respond to corticosteroid therapy. Prospective randomized studies in AIH are needed to validate this observation.
| Original language | English |
|---|---|
| Pages (from-to) | 625-629 |
| Number of pages | 5 |
| Journal | Liver International |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jun 1 2006 |
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Keywords
- Autoimmune hepatitis
- Idiopathic thrombocytopenic purpura
- Monoclonal antibody
- Rituximab
ASJC Scopus subject areas
- Hepatology
Cite this
Successful treatment of autoimmune hepatitis and idiopathic thrombocytopenic purpura with the monoclonal antibody, rituximab : Case report and review of literature. / Santos, Edgardo S.; Arosemena, Leopoldo; Raez, Luis E.; O'Brien, Christopher B; Regev, Arie.
In: Liver International, Vol. 26, No. 5, 01.06.2006, p. 625-629.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful treatment of autoimmune hepatitis and idiopathic thrombocytopenic purpura with the monoclonal antibody, rituximab
T2 - Case report and review of literature
AU - Santos, Edgardo S.
AU - Arosemena, Leopoldo
AU - Raez, Luis E.
AU - O'Brien, Christopher B
AU - Regev, Arie
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Rituximab, a chimeric monoclonal anti-CD20 antibody, has shown activity in several autoimmune disorders. We describe a case of a 52 years old female who was diagnosed with idiopathic thrombocytopenic purpura and concomitant autoimmune hepatitis (AIH), both non-responsive to steroids. She was subsequently treated with rituximab, which resulted in a rapid increase in her platelet count and an unexpected normalization of her hepatic biochemical tests. Both her platelet count and her hepatic biochemical tests remained normal for over 5 months. In this case, rituximab showed an impressive clinical response for the treatment of AIH, and it may be considered as an alternative treatment in patients who do not respond to corticosteroid therapy. Prospective randomized studies in AIH are needed to validate this observation.
AB - Rituximab, a chimeric monoclonal anti-CD20 antibody, has shown activity in several autoimmune disorders. We describe a case of a 52 years old female who was diagnosed with idiopathic thrombocytopenic purpura and concomitant autoimmune hepatitis (AIH), both non-responsive to steroids. She was subsequently treated with rituximab, which resulted in a rapid increase in her platelet count and an unexpected normalization of her hepatic biochemical tests. Both her platelet count and her hepatic biochemical tests remained normal for over 5 months. In this case, rituximab showed an impressive clinical response for the treatment of AIH, and it may be considered as an alternative treatment in patients who do not respond to corticosteroid therapy. Prospective randomized studies in AIH are needed to validate this observation.
KW - Autoimmune hepatitis
KW - Idiopathic thrombocytopenic purpura
KW - Monoclonal antibody
KW - Rituximab
UR - http://www.scopus.com/inward/record.url?scp=33646809309&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646809309&partnerID=8YFLogxK
U2 - 10.1111/j.1478-3231.2006.01262.x
DO - 10.1111/j.1478-3231.2006.01262.x
M3 - Article
C2 - 16762009
AN - SCOPUS:33646809309
VL - 26
SP - 625
EP - 629
JO - Liver International
JF - Liver International
SN - 1478-3223
IS - 5
ER -