Successful transplantation of marrow from an HLA-A, -B, -D mismatched heterozygous sibling donor into an HLA-D-homozygous patient with aplastic anemia

R. J. O'Reilly, R. Pahwa, D. Kirkpatrick, M. Sorell, A. Kapadia, N. Kapoor, J. A. Hansen, M. Pollack, S. E. Schutzer, R. A. Good, B. Dupont

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A patient with aplastic anemia who was found to be homozygous for an HLA-D determinant shared by her unrelated parents achieved sustained engraftment and full restoration of hematopoietic and lymphoid function following a transplant from an HLA-A and -B nonidentical, ABO incompatible sibling who was heterozygous for the shared HLA-D specificity. Transplantation was complicated by transient graft-versus-host disease of moderate severity, which resolved completely following treatment with antithymocyte globulin and prednisone. The case indicates that patients found to be HLA-D-homozygous may be successfully transplanted from HLA-D heterozygous sibling donors despite HLA-A and HLA-B incompatibilities, and thus further demonstrates the importance of the HLA-D region as a marker of donor-host histocompatibility.

Original languageEnglish (US)
Pages (from-to)957-962
Number of pages6
JournalTransplantation proceedings
Volume10
Issue number4
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    O'Reilly, R. J., Pahwa, R., Kirkpatrick, D., Sorell, M., Kapadia, A., Kapoor, N., Hansen, J. A., Pollack, M., Schutzer, S. E., Good, R. A., & Dupont, B. (1978). Successful transplantation of marrow from an HLA-A, -B, -D mismatched heterozygous sibling donor into an HLA-D-homozygous patient with aplastic anemia. Transplantation proceedings, 10(4), 957-962.