Successful transplantation of marrow from an HLA-A, -B, -D mismatched heterozygous sibling donor into an HLA-D-homozygous patient with aplastic anemia

R. J. O'Reilly, Rajendra Pahwa, D. Kirkpatrick, M. Sorell, A. Kapadia, N. Kapoor, J. A. Hansen, M. Pollack, S. E. Schutzer, R. A. Good, B. Dupont

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A patient with aplastic anemia who was found to be homozygous for an HLA-D determinant shared by her unrelated parents achieved sustained engraftment and full restoration of hematopoietic and lymphoid function following a transplant from an HLA-A and -B nonidentical, ABO incompatible sibling who was heterozygous for the shared HLA-D specificity. Transplantation was complicated by transient graft-versus-host disease of moderate severity, which resolved completely following treatment with antithymocyte globulin and prednisone. The case indicates that patients found to be HLA-D-homozygous may be successfully transplanted from HLA-D heterozygous sibling donors despite HLA-A and HLA-B incompatibilities, and thus further demonstrates the importance of the HLA-D region as a marker of donor-host histocompatibility.

Original languageEnglish (US)
Pages (from-to)957-962
Number of pages6
JournalTransplantation Proceedings
Volume10
Issue number4
StatePublished - 1978
Externally publishedYes

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HLA-D Antigens
HLA-A Antigens
HLA-B Antigens
Aplastic Anemia
Siblings
Transplantation
Bone Marrow
Tissue Donors
Histocompatibility
Antilymphocyte Serum
Graft vs Host Disease
Prednisone
Parents
Transplants

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

O'Reilly, R. J., Pahwa, R., Kirkpatrick, D., Sorell, M., Kapadia, A., Kapoor, N., ... Dupont, B. (1978). Successful transplantation of marrow from an HLA-A, -B, -D mismatched heterozygous sibling donor into an HLA-D-homozygous patient with aplastic anemia. Transplantation Proceedings, 10(4), 957-962.

Successful transplantation of marrow from an HLA-A, -B, -D mismatched heterozygous sibling donor into an HLA-D-homozygous patient with aplastic anemia. / O'Reilly, R. J.; Pahwa, Rajendra; Kirkpatrick, D.; Sorell, M.; Kapadia, A.; Kapoor, N.; Hansen, J. A.; Pollack, M.; Schutzer, S. E.; Good, R. A.; Dupont, B.

In: Transplantation Proceedings, Vol. 10, No. 4, 1978, p. 957-962.

Research output: Contribution to journalArticle

O'Reilly, RJ, Pahwa, R, Kirkpatrick, D, Sorell, M, Kapadia, A, Kapoor, N, Hansen, JA, Pollack, M, Schutzer, SE, Good, RA & Dupont, B 1978, 'Successful transplantation of marrow from an HLA-A, -B, -D mismatched heterozygous sibling donor into an HLA-D-homozygous patient with aplastic anemia', Transplantation Proceedings, vol. 10, no. 4, pp. 957-962.
O'Reilly, R. J. ; Pahwa, Rajendra ; Kirkpatrick, D. ; Sorell, M. ; Kapadia, A. ; Kapoor, N. ; Hansen, J. A. ; Pollack, M. ; Schutzer, S. E. ; Good, R. A. ; Dupont, B. / Successful transplantation of marrow from an HLA-A, -B, -D mismatched heterozygous sibling donor into an HLA-D-homozygous patient with aplastic anemia. In: Transplantation Proceedings. 1978 ; Vol. 10, No. 4. pp. 957-962.
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