Successful Reversal of Pulmonary Hypertension in Eisenmenger Complex

Randas J.V. Batista, José L.V. Santos, Noriaki Takeshita, Lise Eocchino, Paulo N. Lima, Marilu Goehr, Marco A. Cunha, Akira T. Kawaguchi, Tomas A. Salerno

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


We present a case of a 19-year old female with systemic pulmonary artery (PA) pressure due to a congenital ventricular septal defect (VSD) and atrial septal defect (ASD). She was pink at rest and cyanotic on exercise. Lung biopsy revealed grade IV pulmonary vascular changes. As a preliminary step PA was banded to increase right-to-left shunt and decrease aortic (Ao) saturation with consequent decrease in PA saturation. After one year, when she was no longer cyanotic, even on exercise, lung biopsy revealed total regression of pulmonary vascular changes. As a definitive procedure VSD and ASD were closed and PA was debanded. Cardiac catheterization one week postoperatively showed PA pressure to be 50% of systemic pressure. We postulate that reversal of pulmonary vascular changes were due to lowered PA saturation. We further believe that lower PA pressure could have contributed to this regression of pulmonary vascular changes. We performed the same procedure in six more patients with similar positive clinical response. This new concept brings renewed hope to many children who otherwise are candidates for heart lung transplantation.

Original languageEnglish (US)
Pages (from-to)279-280
Number of pages2
JournalArquivos Brasileiros de Cardiologia
Issue number4
StatePublished - Apr 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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