Abstract
A patient with advancing renal failure attributed to focal segmental glomerulosclerosis was found to have marked NK (CD56+) cell expansion and large granular lymphocytic leukemia. Subsequent living-related renal transplantation was accomplished with two early bouts of acute cellular rejection requiring therapy with methylprednisolone and monoclonal antibody OKT3. Chronic triple drug immunosuppressive therapy has substantially reduced the marked NK (CD56+) proliferation. The renal transplantation remains successful after 15 months despite persistent but reduced numbers of circulating NK cells, the potential role of which in the pathogenesis of the underlying nephropathy or the cellular rejection process remains speculative.
| Original language | English |
|---|---|
| Pages (from-to) | 292-297 |
| Number of pages | 6 |
| Journal | Nephron |
| Volume | 72 |
| Issue number | 2 |
| State | Published - Feb 1 1996 |
| Externally published | Yes |
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Keywords
- Lymphocytic leukemia
- Natural killer lymphocytes
- Renal transplant
ASJC Scopus subject areas
- Nephrology
Cite this
Successful renal transplantation in a patient with large granular lymphocytic leukemia with natural killer cell proliferation. / Sibal, José; Valenzuela, Rafael; Tubbs, Ray; Hodge, Ernest; Nally, Joseph.
In: Nephron, Vol. 72, No. 2, 01.02.1996, p. 292-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful renal transplantation in a patient with large granular lymphocytic leukemia with natural killer cell proliferation
AU - Sibal, José
AU - Valenzuela, Rafael
AU - Tubbs, Ray
AU - Hodge, Ernest
AU - Nally, Joseph
PY - 1996/2/1
Y1 - 1996/2/1
N2 - A patient with advancing renal failure attributed to focal segmental glomerulosclerosis was found to have marked NK (CD56+) cell expansion and large granular lymphocytic leukemia. Subsequent living-related renal transplantation was accomplished with two early bouts of acute cellular rejection requiring therapy with methylprednisolone and monoclonal antibody OKT3. Chronic triple drug immunosuppressive therapy has substantially reduced the marked NK (CD56+) proliferation. The renal transplantation remains successful after 15 months despite persistent but reduced numbers of circulating NK cells, the potential role of which in the pathogenesis of the underlying nephropathy or the cellular rejection process remains speculative.
AB - A patient with advancing renal failure attributed to focal segmental glomerulosclerosis was found to have marked NK (CD56+) cell expansion and large granular lymphocytic leukemia. Subsequent living-related renal transplantation was accomplished with two early bouts of acute cellular rejection requiring therapy with methylprednisolone and monoclonal antibody OKT3. Chronic triple drug immunosuppressive therapy has substantially reduced the marked NK (CD56+) proliferation. The renal transplantation remains successful after 15 months despite persistent but reduced numbers of circulating NK cells, the potential role of which in the pathogenesis of the underlying nephropathy or the cellular rejection process remains speculative.
KW - Lymphocytic leukemia
KW - Natural killer lymphocytes
KW - Renal transplant
UR - http://www.scopus.com/inward/record.url?scp=0030046321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030046321&partnerID=8YFLogxK
M3 - Article
C2 - 8684542
AN - SCOPUS:0030046321
VL - 72
SP - 292
EP - 297
JO - Experimental Nephrology
JF - Experimental Nephrology
SN - 0028-2766
IS - 2
ER -