Successful renal transplantation in a patient with large granular lymphocytic leukemia with natural killer cell proliferation

José Sibal, Rafael Valenzuela, Ray Tubbs, Ernest Hodge, Joseph Nally

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A patient with advancing renal failure attributed to focal segmental glomerulosclerosis was found to have marked NK (CD56+) cell expansion and large granular lymphocytic leukemia. Subsequent living-related renal transplantation was accomplished with two early bouts of acute cellular rejection requiring therapy with methylprednisolone and monoclonal antibody OKT3. Chronic triple drug immunosuppressive therapy has substantially reduced the marked NK (CD56+) proliferation. The renal transplantation remains successful after 15 months despite persistent but reduced numbers of circulating NK cells, the potential role of which in the pathogenesis of the underlying nephropathy or the cellular rejection process remains speculative.

Original languageEnglish
Pages (from-to)292-297
Number of pages6
JournalNephron
Volume72
Issue number2
StatePublished - Feb 1 1996
Externally publishedYes

Fingerprint

Large Granular Lymphocytic Leukemia
Natural Killer Cells
Kidney Transplantation
Cell Proliferation
Muromonab-CD3
Focal Segmental Glomerulosclerosis
Methylprednisolone
Immunosuppressive Agents
Renal Insufficiency
Drug Therapy
Therapeutics

Keywords

  • Lymphocytic leukemia
  • Natural killer lymphocytes
  • Renal transplant

ASJC Scopus subject areas

  • Nephrology

Cite this

Sibal, J., Valenzuela, R., Tubbs, R., Hodge, E., & Nally, J. (1996). Successful renal transplantation in a patient with large granular lymphocytic leukemia with natural killer cell proliferation. Nephron, 72(2), 292-297.

Successful renal transplantation in a patient with large granular lymphocytic leukemia with natural killer cell proliferation. / Sibal, José; Valenzuela, Rafael; Tubbs, Ray; Hodge, Ernest; Nally, Joseph.

In: Nephron, Vol. 72, No. 2, 01.02.1996, p. 292-297.

Research output: Contribution to journalArticle

Sibal, J, Valenzuela, R, Tubbs, R, Hodge, E & Nally, J 1996, 'Successful renal transplantation in a patient with large granular lymphocytic leukemia with natural killer cell proliferation', Nephron, vol. 72, no. 2, pp. 292-297.
Sibal, José ; Valenzuela, Rafael ; Tubbs, Ray ; Hodge, Ernest ; Nally, Joseph. / Successful renal transplantation in a patient with large granular lymphocytic leukemia with natural killer cell proliferation. In: Nephron. 1996 ; Vol. 72, No. 2. pp. 292-297.
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