Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatoy infertility.

A. Zárate; E. S. Canales; A. V. Schally; L. Ayala-Valdés; A. J. Kastin

doi:10.1016/s0015-0282(16)39196-8

Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatoy infertility.

A. Zárate, E. S. Canales, A. V. Schally, L. Ayala-Valdés, A. J. Kastin

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens. 3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg. 10 days later the infusion was repeated without the supplemental injecti on and coitus advised immediately after the end of the 2nd infusion. 10 patients were given LH-RH by injection of 50 mch/day for 10 days. Coitus was indicated every other day from Day 8 of therapy. Presumptive ovulation was determined on each mode of therapy. 2 of the 3 intravenous patients had presumptive ovulation responses wihtout conception. 4 of the 10 injection patients had presumptive ovulation signs and 2 conceived. The 6 remaining injection patients responded with increased estrogens and estrogenic effect on cervical mucus. The results confirm the therapeutic role of LH-RH in certain cases of sterility.

Original language	English (US)
Pages (from-to)	672-674
Number of pages	3
Journal	Fertility and sterility
Volume	23
Issue number	9
DOIs	https://doi.org/10.1016/s0015-0282(16)39196-8
State	Published - Sep 1972
Externally published	Yes

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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title = "Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatoy infertility.",

abstract = "13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens. 3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg. 10 days later the infusion was repeated without the supplemental injecti on and coitus advised immediately after the end of the 2nd infusion. 10 patients were given LH-RH by injection of 50 mch/day for 10 days. Coitus was indicated every other day from Day 8 of therapy. Presumptive ovulation was determined on each mode of therapy. 2 of the 3 intravenous patients had presumptive ovulation responses wihtout conception. 4 of the 10 injection patients had presumptive ovulation signs and 2 conceived. The 6 remaining injection patients responded with increased estrogens and estrogenic effect on cervical mucus. The results confirm the therapeutic role of LH-RH in certain cases of sterility.",

author = "A. Z{\'a}rate and Canales, {E. S.} and Schally, {A. V.} and L. Ayala-Vald{\'e}s and Kastin, {A. J.}",

year = "1972",

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doi = "10.1016/s0015-0282(16)39196-8",

language = "English (US)",

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AU - Zárate, A.

AU - Canales, E. S.

AU - Schally, A. V.

AU - Ayala-Valdés, L.

AU - Kastin, A. J.

PY - 1972/9

Y1 - 1972/9

N2 - 13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens. 3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg. 10 days later the infusion was repeated without the supplemental injecti on and coitus advised immediately after the end of the 2nd infusion. 10 patients were given LH-RH by injection of 50 mch/day for 10 days. Coitus was indicated every other day from Day 8 of therapy. Presumptive ovulation was determined on each mode of therapy. 2 of the 3 intravenous patients had presumptive ovulation responses wihtout conception. 4 of the 10 injection patients had presumptive ovulation signs and 2 conceived. The 6 remaining injection patients responded with increased estrogens and estrogenic effect on cervical mucus. The results confirm the therapeutic role of LH-RH in certain cases of sterility.

AB - 13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens. 3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg. 10 days later the infusion was repeated without the supplemental injecti on and coitus advised immediately after the end of the 2nd infusion. 10 patients were given LH-RH by injection of 50 mch/day for 10 days. Coitus was indicated every other day from Day 8 of therapy. Presumptive ovulation was determined on each mode of therapy. 2 of the 3 intravenous patients had presumptive ovulation responses wihtout conception. 4 of the 10 injection patients had presumptive ovulation signs and 2 conceived. The 6 remaining injection patients responded with increased estrogens and estrogenic effect on cervical mucus. The results confirm the therapeutic role of LH-RH in certain cases of sterility.

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SN - 0015-0282

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Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatoy infertility.

Abstract

ASJC Scopus subject areas

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