Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatoy infertility.

13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens. 3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg. 10 days later the infusion was repeated without the supplemental injecti on and coitus advised immediately after the end of the 2nd infusion. 10 patients were given LH-RH by injection of 50 mch/day for 10 days. Coitus was indicated every other day from Day 8 of therapy. Presumptive ovulation was determined on each mode of therapy. 2 of the 3 intravenous patients had presumptive ovulation responses wihtout conception. 4 of the 10 injection patients had presumptive ovulation signs and 2 conceived. The 6 remaining injection patients responded with increased estrogens and estrogenic effect on cervical mucus. The results confirm the therapeutic role of LH-RH in certain cases of sterility.