Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatoy infertility.

A. Zárate, E. S. Canales, A. V. Schally, L. Ayala-Valdés, A. J. Kastin

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

13 women with suspected hypothalamic anovulation were treated with l uteinizing hormone-releasing hormone (LH-RH) by a variety of regimens. 3 women received LH-RH by continuous intravenous infusion equal to 100 mcg LH-RH for 8 hours, followed by an acute injection of LH-RH 100 mcg. 10 days later the infusion was repeated without the supplemental injecti on and coitus advised immediately after the end of the 2nd infusion. 10 patients were given LH-RH by injection of 50 mch/day for 10 days. Coitus was indicated every other day from Day 8 of therapy. Presumptive ovulation was determined on each mode of therapy. 2 of the 3 intravenous patients had presumptive ovulation responses wihtout conception. 4 of the 10 injection patients had presumptive ovulation signs and 2 conceived. The 6 remaining injection patients responded with increased estrogens and estrogenic effect on cervical mucus. The results confirm the therapeutic role of LH-RH in certain cases of sterility.

Original languageEnglish (US)
Pages (from-to)672-674
Number of pages3
JournalFertility and sterility
Volume23
Issue number9
DOIs
StatePublished - Sep 1972

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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