Successful immunosuppressant therapy of severe progressive cerebellar degeneration and sensory neuropathy: A case report

Nima Mowzoon, Walter G Bradley

Research output: Contribution to journalArticle

14 Scopus citations


A 56 year old woman had a 19 month history of a severe subacute progressive cerebellar degeneration, peripheral sensory neuropathy, and urinary incontinence. She was confined to a wheelchair, needed assistance with eating, and her speech was almost unintelligible. No underlying cancer was found despite repeated investigations, and no autoantibodies were demonstrated. She received a 3-month course of intensive immunosuppressant therapy with intravenous immunoglobulin 400 mg/kg per day for 5 days every month, oral cyclophosphamide 50 mg twice or three times a day to maintain the total lymphocyte count between 500 and 750/mm3, and prednisone 60 mg per day. She experienced dramatic subjective and objective improvement. The dysarthria and the upper extremity dysmetria disappeared, and she regained the ability to write and cook. The lower extremity ataxia improved and she became able to walk with a cane. Urinary incontinence disappeared. A trial of intensive immunosuppressant treatment is worth considering in a patient with a clinical syndrome resembling paraneoplastic disorders, even if an underlying neoplasm and autoantibodies are not demonstrated. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalJournal of the Neurological Sciences
Issue number1
StatePublished - Sep 1 2000



  • Autonomic neuropathy
  • Cerebellar degeneration
  • Immunosuppressant therapy
  • Sensory neuropathy

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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