Successful control of systemic aspergillus niger infections in two patients with acute leukemia

Felipe G. Gercovich, Stephen P Richman, Victorio Rodriguez, Mario Luna, Kenneth B. McCredie, Gerald P. Bodey

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The diagnosis and successful control of systemic Aspergillus niger infection in 2 adult patients with acute leukemia is reported. During induction therapy, the first patient developed pulmonary infiltrates, skin lesions and abnormal liver function tests. Aspergillus niger was found on skin and liver biopsy. This patient was successfully treated with Amphotericin B and granulocyte transfusions and he remains in remission. The second patient developed a pneumonitis and adynamic ileus with positive sputum and stool cultures for Aspergillus niger. The infection only responded to Amphotericin B and granulocyte transfusions and the leukemia to cytoreductive chemotherapy. The patient later relapsed and died after a febrile illness. Fungi morphologically consistent with Aspergillus were found in the liver at autopsy. Infection with A. niger is rare even in this patient population; however fungal infections have become an increasing problem. The need for a high index of suspicion, especially when an infection is unresponsive to antibacterial antibiotics, the various diagnostic tools, and the need for aggressive therapy are stressed. Amphotericin B is the chemotherapy of choice but may be insufficient in a severely neutropenic host where the simultaneous use of granulocyte transfusions might be lifesaving.

Original languageEnglish (US)
Pages (from-to)2271-2276
Number of pages6
JournalCancer
Volume36
Issue number6
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

Fingerprint

Leukemia
Amphotericin B
Granulocytes
Aspergillus niger
Drug Therapy
Skin
Mycoses
Ileus
Liver
Liver Function Tests
Aspergillus
Infection
Sputum
Aspergillus niger infection
Autopsy
Pneumonia
Fungi
Fever
Anti-Bacterial Agents
Biopsy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Gercovich, F. G., Richman, S. P., Rodriguez, V., Luna, M., McCredie, K. B., & Bodey, G. P. (1975). Successful control of systemic aspergillus niger infections in two patients with acute leukemia. Cancer, 36(6), 2271-2276. https://doi.org/10.1002/cncr.2820360945

Successful control of systemic aspergillus niger infections in two patients with acute leukemia. / Gercovich, Felipe G.; Richman, Stephen P; Rodriguez, Victorio; Luna, Mario; McCredie, Kenneth B.; Bodey, Gerald P.

In: Cancer, Vol. 36, No. 6, 01.01.1975, p. 2271-2276.

Research output: Contribution to journalArticle

Gercovich, FG, Richman, SP, Rodriguez, V, Luna, M, McCredie, KB & Bodey, GP 1975, 'Successful control of systemic aspergillus niger infections in two patients with acute leukemia', Cancer, vol. 36, no. 6, pp. 2271-2276. https://doi.org/10.1002/cncr.2820360945
Gercovich, Felipe G. ; Richman, Stephen P ; Rodriguez, Victorio ; Luna, Mario ; McCredie, Kenneth B. ; Bodey, Gerald P. / Successful control of systemic aspergillus niger infections in two patients with acute leukemia. In: Cancer. 1975 ; Vol. 36, No. 6. pp. 2271-2276.
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