Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish

Digna R Velez Edwards, John Gilbert, Lan Jiang, Paul J. Gallins, Laura Caywood, Marilyn Creason, Denise Fuzzell, Clare Knebusch, Charles E. Jackson, Margaret A Pericak-Vance, Jonathan L. Haines, William K Scott

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.

Original languageEnglish
Pages (from-to)516-528
Number of pages13
JournalAnnals of Human Genetics
Volume75
Issue number4
DOIs
StatePublished - Jul 1 2011

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Keywords

  • Amish
  • Family-based study
  • Genetic epidemiology
  • Longevity
  • Population isolate

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Edwards, D. R. V., Gilbert, J., Jiang, L., Gallins, P. J., Caywood, L., Creason, M., Fuzzell, D., Knebusch, C., Jackson, C. E., Pericak-Vance, M. A., Haines, J. L., & Scott, W. K. (2011). Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish. Annals of Human Genetics, 75(4), 516-528. https://doi.org/10.1111/j.1469-1809.2011.00658.x