Abstract
Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.
Original language | English (US) |
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Pages (from-to) | 516-528 |
Number of pages | 13 |
Journal | Annals of Human Genetics |
Volume | 75 |
Issue number | 4 |
DOIs | |
State | Published - Jul 2011 |
Keywords
- Amish
- Family-based study
- Genetic epidemiology
- Longevity
- Population isolate
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics