Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish

Digna R.Velez Edwards, John R. Gilbert, Lan Jiang, Paul J. Gallins, Laura Caywood, Marilyn Creason, Denise Fuzzell, Clare Knebusch, Charles E. Jackson, Margaret A. Pericak-Vance, Jonathan L. Haines, William K. Scott

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.

Original languageEnglish (US)
Pages (from-to)516-528
Number of pages13
JournalAnnals of Human Genetics
Volume75
Issue number4
DOIs
StatePublished - Jul 1 2011

Keywords

  • Amish
  • Family-based study
  • Genetic epidemiology
  • Longevity
  • Population isolate

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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    Edwards, D. R. V., Gilbert, J. R., Jiang, L., Gallins, P. J., Caywood, L., Creason, M., Fuzzell, D., Knebusch, C., Jackson, C. E., Pericak-Vance, M. A., Haines, J. L., & Scott, W. K. (2011). Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish. Annals of Human Genetics, 75(4), 516-528. https://doi.org/10.1111/j.1469-1809.2011.00658.x