Abstract
Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.
| Original language | English |
|---|---|
| Pages (from-to) | 516-528 |
| Number of pages | 13 |
| Journal | Annals of Human Genetics |
| Volume | 75 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1 2011 |
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Keywords
- Amish
- Family-based study
- Genetic epidemiology
- Longevity
- Population isolate
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
Cite this
Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish. / Edwards, Digna R Velez; Gilbert, John; Jiang, Lan; Gallins, Paul J.; Caywood, Laura; Creason, Marilyn; Fuzzell, Denise; Knebusch, Clare; Jackson, Charles E.; Pericak-Vance, Margaret A; Haines, Jonathan L.; Scott, William K.
In: Annals of Human Genetics, Vol. 75, No. 4, 01.07.2011, p. 516-528.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Successful Aging Shows Linkage to Chromosomes 6, 7, and 14 in the Amish
AU - Edwards, Digna R Velez
AU - Gilbert, John
AU - Jiang, Lan
AU - Gallins, Paul J.
AU - Caywood, Laura
AU - Creason, Marilyn
AU - Fuzzell, Denise
AU - Knebusch, Clare
AU - Jackson, Charles E.
AU - Pericak-Vance, Margaret A
AU - Haines, Jonathan L.
AU - Scott, William K
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.
AB - Successful aging (SA) is a multidimensional phenotype involving preservation of cognitive ability, physical function, and social engagement throughout life. Multiple components of SA are heritable, supporting a genetic component. The Amish are genetically and socially isolated with homogeneous lifestyles, making them a suitable population for studying the genetics of SA. DNA and measures of SA were collected on 214 cognitively intact Amish individuals over age 80. Individuals were grouped into a 13-generation pedigree using the Anabaptist Genealogy Database. A linkage screen of 5944 single nucleotide polymorphisms (SNPs) was performed using 12 informative subpedigrees with an affected-only 2-point and multipoint linkage analysis. Eleven SNPs produced 2-point LOD scores >2, suggestive of linkage. Multipoint linkage analyses, allowing for heterogeneity, detected significant LOD scores on chromosomes 6 (HLOD = 4.50), 7 (LOD*= 3.11), and 14 (HLOD = 4.17), suggesting multiple new loci underlying SA.
KW - Amish
KW - Family-based study
KW - Genetic epidemiology
KW - Longevity
KW - Population isolate
UR - http://www.scopus.com/inward/record.url?scp=79958859806&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958859806&partnerID=8YFLogxK
U2 - 10.1111/j.1469-1809.2011.00658.x
DO - 10.1111/j.1469-1809.2011.00658.x
M3 - Article
C2 - 21668908
AN - SCOPUS:79958859806
VL - 75
SP - 516
EP - 528
JO - Annals of Human Genetics
JF - Annals of Human Genetics
SN - 0003-4800
IS - 4
ER -