Substance P, thyrotropin-releasing hormone, and monoamine metabolites in cerebrospinal fluid in sleep apnea patients

T. Gislason, J. Hedner, L. Terenius, G. Bisette, C. B. Nemeroff

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The cerebrospinal fluid (CSF) concentrations of thyrotropin-releasing hormone (TRH), substance P (SP), 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 15 consecutive patients with the sleep apnea syndrome (SAS) and in healthy control subjects. Second measurements were performed 6 months after surgical treatment in 10 of the patients. The mean (± SD) concentration of TRH-like immunoreactive material (TRH-LIM) (pg/ml) did not differ significantly between patients with SAS (8.1 ± 2.8) and control subjects (7.5 ± 2.2). However, postoperatively, this concentration was increased in the six clinically cured patients with SAS, from 6.9 ± 2.7 to 9.4 ± 1.6 (p < 0.03). Substance P-like immunoreactive material (SP-LIM) was higher in untreated patients with SAS than in control subjects: 19.2 ± 6.7 versus 14.4 ± 4.2 fmol/ml (p < 0.02), and the level remained high after operation in the group treated surgically. The HVA, 5-HIAA, and MHPG concentrations were similar in patients with SAS and control subjects, and no consistent changes were found postoperatively. The CSF deviations in TRH-LIM and SP-LIM concentrations in the patients may reflect a primary central nervous system defect or they may be secondary to intermittent nocturnal hypoxia, progressive hypercapnia, and/or sleep fragmentation. In this sense, both these systems may be markers of SAS-SP as a 'trait' marker and TRH as an indicator of the current state.

Original languageEnglish (US)
Pages (from-to)784-786
Number of pages3
JournalAmerican Review of Respiratory Disease
Issue number3
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Substance P, thyrotropin-releasing hormone, and monoamine metabolites in cerebrospinal fluid in sleep apnea patients'. Together they form a unique fingerprint.

Cite this