Subsets of axonally transported and periaxonal polypeptides are released from regenerating nerve

B. Tedeschi, D. L. Wilson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Using two-dimensional polyacrylamide gel electrophoresis to analyze proteins, we have found subsets of periaxonal and fast-transported axoplasmic proteins that are released in vitro from regenerating sciatic nerve into a surrounding bath. Of the fast-transported proteins that are released from nerve, there is a subset of at least five polypeptides that appears in greater relative abundance in the bath than in the nerve. Some of these released, fast-transported proteins are glycosylated. Several periaxonally synthesized polypeptides are released in significantly greater amounts from regenerating nerve, and of these polypeptides, two are released in greater amounts from nerve only at regions of regeneration or distal to regeneration. These released polypeptides do not represent the most abundant of the locally synthesized proteins. The released, fast-transported and periaxonal proteins may play a role in intercellular signaling or in modulation of the extracellular environment during nerve regeneration.

Original languageEnglish
Pages (from-to)463-469
Number of pages7
JournalJournal of Neurochemistry
Volume48
Issue number2
StatePublished - Jan 1 1987

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Peptides
Proteins
Baths
Regeneration
Nerve Regeneration
Electrophoresis, Gel, Two-Dimensional
Sciatic Nerve
Electrophoresis
Modulation

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Subsets of axonally transported and periaxonal polypeptides are released from regenerating nerve. / Tedeschi, B.; Wilson, D. L.

In: Journal of Neurochemistry, Vol. 48, No. 2, 01.01.1987, p. 463-469.

Research output: Contribution to journalArticle

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