Abstract
Neurotensin has been shown to possess many pharmacological properties that are similar to those of neuroleptic drugs. The authors determined CSF levels of immunoreactive neurotensin in 12 normal healthy volunteers and in 21 schizophrenic patients during both drug-free and neuroleptic-treated phases. In contrast to the healthy volunteers, the schizophrenic patients showed a bimodal distribution of the peptide during the drug-free phase. A subgroup of 9 schizophrenic patients had markedly lower levels than the rest of the schizophrenic patients, whose levels were comparable to those of the healthy volunteers. During neuroleptic treatment, the CSF levels of the 9 schizophrenic patients with initially low values rose to normal concentration.
| Original language | English |
|---|---|
| Pages (from-to) | 1122-1126 |
| Number of pages | 5 |
| Journal | American Journal of Psychiatry |
| Volume | 139 |
| Issue number | 9 |
| State | Published - Oct 25 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients : Normalization after neuroleptic treatment. / Widerlov, E.; Lindstrom, L. H.; Besev, G.; Manberg, P. J.; Nemeroff, Charles; Breese, G. R.; Kizer, J. S.; Prange, A. J.
In: American Journal of Psychiatry, Vol. 139, No. 9, 25.10.1982, p. 1122-1126.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients
T2 - Normalization after neuroleptic treatment
AU - Widerlov, E.
AU - Lindstrom, L. H.
AU - Besev, G.
AU - Manberg, P. J.
AU - Nemeroff, Charles
AU - Breese, G. R.
AU - Kizer, J. S.
AU - Prange, A. J.
PY - 1982/10/25
Y1 - 1982/10/25
N2 - Neurotensin has been shown to possess many pharmacological properties that are similar to those of neuroleptic drugs. The authors determined CSF levels of immunoreactive neurotensin in 12 normal healthy volunteers and in 21 schizophrenic patients during both drug-free and neuroleptic-treated phases. In contrast to the healthy volunteers, the schizophrenic patients showed a bimodal distribution of the peptide during the drug-free phase. A subgroup of 9 schizophrenic patients had markedly lower levels than the rest of the schizophrenic patients, whose levels were comparable to those of the healthy volunteers. During neuroleptic treatment, the CSF levels of the 9 schizophrenic patients with initially low values rose to normal concentration.
AB - Neurotensin has been shown to possess many pharmacological properties that are similar to those of neuroleptic drugs. The authors determined CSF levels of immunoreactive neurotensin in 12 normal healthy volunteers and in 21 schizophrenic patients during both drug-free and neuroleptic-treated phases. In contrast to the healthy volunteers, the schizophrenic patients showed a bimodal distribution of the peptide during the drug-free phase. A subgroup of 9 schizophrenic patients had markedly lower levels than the rest of the schizophrenic patients, whose levels were comparable to those of the healthy volunteers. During neuroleptic treatment, the CSF levels of the 9 schizophrenic patients with initially low values rose to normal concentration.
UR - http://www.scopus.com/inward/record.url?scp=0019943369&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019943369&partnerID=8YFLogxK
M3 - Article
C2 - 6126127
AN - SCOPUS:0019943369
VL - 139
SP - 1122
EP - 1126
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 9
ER -