Subdural hematoma decompression model: A model of traumatic brain injury with ischemic-reperfusional pathophysiology: A review of the literature

Shoji Yokobori, Ryuta Nakae, Hiroyuki Yokota, Markus S. Spurlock, Stefania Mondello, Shyam Gajavelli, Ross Bullock

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The prognosis for patients with traumatic brain injury (TBI) with subdural hematoma (SDH) remains poor. In accordance with an increasing elderly population, the incidence of geriatric TBI with SDH is rising.An important contributor to the neurological injury associated with SDH is the ischemic damage which is caused by raised intracranial pressure (ICP) producing impaired cerebral perfusion. To control intracranial hypertension, the current management consists of hematoma evacuation with or without decompressive craniotomy. This removal of the SDH results in the immediate reversal of global ischemia accompanied by an abrupt reduction of mass lesion and an ensuing reperfusion injury. Experimental models can play a critical role in improving our understanding of the underlying pathophysiology and in exploring potential treatments for patients with SDH.In this review, we describe the epidemiology, pathophysiology and clinical background of SDH.

Original languageEnglish (US)
JournalBehavioural Brain Research
DOIs
StateAccepted/In press - Mar 4 2016

Keywords

  • Decompressive craniotomy
  • Ischemic/reperfusional brain injury
  • Subdural hematoma
  • Therapeutic hypothermia
  • Traumatic brain injury

ASJC Scopus subject areas

  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Subdural hematoma decompression model: A model of traumatic brain injury with ischemic-reperfusional pathophysiology: A review of the literature'. Together they form a unique fingerprint.

  • Cite this