Subdural EEC patterns in children with taylor-type cortical dysplasia: Comparison with nondysplastic lesions

Dilsad Turkdogan, Michael Duchowny, Trevor Resnick, Prasanna Jayakar

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The authors compared interictal and ictal abnormalities from chronic intracranial recordings in children with Taylor-type cortical dysplasia (TTCD) and nondysplastic lesions. Interictal epileptiform discharges and ictal patterns were retrospectively analyzed in 13 children with TTCD and 12 children with nondysplastic lesions (tumor, 4; gliosis, 8). Features analyzed and compared between groups included the morphologic and temporal characteristics and field distribution of ictal and interictal patterns and rapidity of ictal propagation. The frequency of runs of interictal continuous epileptiform discharges (CEDs) or bursts of fast activity did not differ significantly between dysplastic and nondysplastic tissue. Fast frequencies characterized the majority of seizure onsets (49/67) in dysplastic patients and repetitive spikes were more frequent at seizure onset (31/56) in nondysplastic patients (P < 0.002). Field of ictal onset was limited to adjacent cortex and independent of histology. The interval between seizure onset and spread to adjacent or nonadjacent cortex was significantly shorter in dysplastic than nondysplastic patients. Interictal EEG patterns are not specific markers of dysplastic cortex but the morphology of ictal onset differs significantly with dysplastic cortex showing significantly more rapid propagation than nondysplastic cortex. These findings suggest that markers other than CEDs physiologically characterize dysplastic cortex and that children with TTCD exhibit more widespread excitability of neural pathways.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalJournal of Clinical Neurophysiology
Volume22
Issue number1
DOIs
StatePublished - Feb 15 2005

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European Union
Stroke
Seizures
Neural Pathways
Gliosis
Focal cortical dysplasia of Taylor
Electroencephalography
Histology
Neoplasms

Keywords

  • Chronic intracranial monitoring
  • Interictal and ictal patterns
  • Taylor-type cortical dysplasia

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology
  • Neuroscience(all)

Cite this

Subdural EEC patterns in children with taylor-type cortical dysplasia : Comparison with nondysplastic lesions. / Turkdogan, Dilsad; Duchowny, Michael; Resnick, Trevor; Jayakar, Prasanna.

In: Journal of Clinical Neurophysiology, Vol. 22, No. 1, 15.02.2005, p. 37-42.

Research output: Contribution to journalArticle

Turkdogan, Dilsad ; Duchowny, Michael ; Resnick, Trevor ; Jayakar, Prasanna. / Subdural EEC patterns in children with taylor-type cortical dysplasia : Comparison with nondysplastic lesions. In: Journal of Clinical Neurophysiology. 2005 ; Vol. 22, No. 1. pp. 37-42.
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