Subacute encephalitis in acquired immune deficiency syndrome: A postmortem study

S. L. Nielsen, Carol Petito, C. D. Urmacher, J. B. Posner

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Thirty-one out of 40 patients with the acquired immune deficiency syndrome examined at autopsy had significant central nervous system disease. A subacute encephalitis, found in 19 patients, was the most frequent finding and was characterized by marked brain atrophy and a progressive dementing illness. This entity is linked to cytomegalovirus (CMV) by typical histopathology and association with systemic CMV infection with supportive evidence of positive immunohistochemical staining of tissue sections and, in one case, identification of CMV-type viral particles by electron microscopy. However, brain tissue cultures have been negative, making the etiology of subacute encephalitis not entirely clear.

Original languageEnglish
Pages (from-to)678-682
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume82
Issue number6
StatePublished - Dec 1 1984
Externally publishedYes

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Encephalitis
Cytomegalovirus
Acquired Immunodeficiency Syndrome
Central Nervous System Diseases
Cytomegalovirus Infections
Brain
Virion
Atrophy
Autopsy
Electron Microscopy
Staining and Labeling

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nielsen, S. L., Petito, C., Urmacher, C. D., & Posner, J. B. (1984). Subacute encephalitis in acquired immune deficiency syndrome: A postmortem study. American Journal of Clinical Pathology, 82(6), 678-682.

Subacute encephalitis in acquired immune deficiency syndrome : A postmortem study. / Nielsen, S. L.; Petito, Carol; Urmacher, C. D.; Posner, J. B.

In: American Journal of Clinical Pathology, Vol. 82, No. 6, 01.12.1984, p. 678-682.

Research output: Contribution to journalArticle

Nielsen, SL, Petito, C, Urmacher, CD & Posner, JB 1984, 'Subacute encephalitis in acquired immune deficiency syndrome: A postmortem study', American Journal of Clinical Pathology, vol. 82, no. 6, pp. 678-682.
Nielsen, S. L. ; Petito, Carol ; Urmacher, C. D. ; Posner, J. B. / Subacute encephalitis in acquired immune deficiency syndrome : A postmortem study. In: American Journal of Clinical Pathology. 1984 ; Vol. 82, No. 6. pp. 678-682.
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