Study on the recovery of pituitary FSH function during puerperium using synthetic LRH

Elías S. Canales, Arturo Zárate, José Garrido, Carlos León, Jorge Soria, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Eleven women received synthetic LRH by a single iv injection 48 hr postpartum. Seven of 11 received again LRH on day 15 postpartum. Serum concentration of FSH in the immediate postpartum and FSH and LH 15 days after delivery were measured by radioimmunoassy. Serum FSH was undetectable 48 hr following delivery and LRH failed to increase FSH concentration. On day 15 postpartum baseline levels of FSH were within normal limits and LH concentration was below normal as compared with follicular phase values of the menstrual cycle. FSH release in response to LRH was greater and LH release was diminished when compared to that observed in normal menstruating women. It is concluded that recovery of pituitary function is faster for FSH than for LH following delivery, and that 15 days after delivery a reversal from menstruating women on the FSH/LH secretory responsiveness to LRH is observed.

Original languageEnglish (US)
Pages (from-to)1140-1142
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
StatePublished - Jan 1 1974
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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