Study on Myocardial Contractility after Cardiopulmonary Bypass versus Cardioplegic Arrest in an Air-Ejecting In Vivo Heart Model

Amin Mohamed G. Addetia, Samuel V. Lichtenstein, Aida S. Ko, Maija Sikkonen, Murli Sainani, Tomas A. Salerno

Research output: Contribution to journalArticle


Cardiac function was assessed in a working in vivo canine heart preparation. Minute work and myocardial oxygen consumption (MV(O2)) were measured after a two-hour period of hypothermic hyperkalemic crystalloid cardioplegic arrest in one group of dogs (Group 1, N = 6) and in another group of dogs on cardiopulmonary bypass (CPB) alone (Group 2, N = 6). Results indicate that at an afterload of 50 cm H2O, minute work was the same in all hearts but MV(O2) was significantly higher in Group 1 hearts at all levels of preload. At higher afterloads, both minute work and MV(O2) were significantly greater in Group 1 hearts over the range of preloads tested. Ventricular compliance was decreased in Group 1 over the range of preloads studied. These results suggest that heart undergoing cardioplegia arrest had better left ventricular contractility than hearts undergoing CPB alone.

Original languageEnglish (US)
Pages (from-to)260-264
Number of pages5
JournalAnnals of Thoracic Surgery
Issue number3
StatePublished - Jan 1 1986
Externally publishedYes


ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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