Study on myocardial contractility after cardiopulmonary bypass versus cardioplegic arrest in an air-ejecting in vivo heart model

A. M G Addetia, S. V. Lichtenstein, A. S. Ko, M. Sikkonen, M. Sainani, Tomas Salerno

Research output: Contribution to journalArticle

Abstract

Cardiac function was assessed in a working in vivo canine heart preparation. Minute work and myocardial oxygen consumption (MV(O2)) were measured after a two-hour period of hypothermic hyperkalemic crystalloid cardioplegic arrest in one group of dogs (Group 1, N = 6) and in another group of dogs on cardiopulmonary bypass (CPB) alone (Group 2, N = 6). Results indicate that at an afterload of 50 cm H2O, minute work was the same in all hearts but MV(O2) was significantly higher in Group 1 hearts at all levels of preload. At higher afterloads, both minute work and MV(O2) were significantly greater in Group 1 hearts over the range of preloads tested. Ventricular compliance was decreased in Group 1 over the range of preloads studied. These results suggest that heart undergoing cardioplegia arrest had better left ventricular contractility than hearts undergoing CPB alone.

Original languageEnglish
Pages (from-to)260-264
Number of pages5
JournalAnnals of Thoracic Surgery
Volume41
Issue number3
StatePublished - Jun 11 1986
Externally publishedYes

Fingerprint

Cardiopulmonary Bypass
Air
Dogs
Myocardial Contraction
Induced Heart Arrest
Oxygen Consumption
Compliance
Canidae

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Study on myocardial contractility after cardiopulmonary bypass versus cardioplegic arrest in an air-ejecting in vivo heart model. / Addetia, A. M G; Lichtenstein, S. V.; Ko, A. S.; Sikkonen, M.; Sainani, M.; Salerno, Tomas.

In: Annals of Thoracic Surgery, Vol. 41, No. 3, 11.06.1986, p. 260-264.

Research output: Contribution to journalArticle

Addetia, A. M G ; Lichtenstein, S. V. ; Ko, A. S. ; Sikkonen, M. ; Sainani, M. ; Salerno, Tomas. / Study on myocardial contractility after cardiopulmonary bypass versus cardioplegic arrest in an air-ejecting in vivo heart model. In: Annals of Thoracic Surgery. 1986 ; Vol. 41, No. 3. pp. 260-264.
@article{a6e5cf9a94b54590a170e23a39febe0d,
title = "Study on myocardial contractility after cardiopulmonary bypass versus cardioplegic arrest in an air-ejecting in vivo heart model",
abstract = "Cardiac function was assessed in a working in vivo canine heart preparation. Minute work and myocardial oxygen consumption (MV(O2)) were measured after a two-hour period of hypothermic hyperkalemic crystalloid cardioplegic arrest in one group of dogs (Group 1, N = 6) and in another group of dogs on cardiopulmonary bypass (CPB) alone (Group 2, N = 6). Results indicate that at an afterload of 50 cm H2O, minute work was the same in all hearts but MV(O2) was significantly higher in Group 1 hearts at all levels of preload. At higher afterloads, both minute work and MV(O2) were significantly greater in Group 1 hearts over the range of preloads tested. Ventricular compliance was decreased in Group 1 over the range of preloads studied. These results suggest that heart undergoing cardioplegia arrest had better left ventricular contractility than hearts undergoing CPB alone.",
author = "Addetia, {A. M G} and Lichtenstein, {S. V.} and Ko, {A. S.} and M. Sikkonen and M. Sainani and Tomas Salerno",
year = "1986",
month = "6",
day = "11",
language = "English",
volume = "41",
pages = "260--264",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Study on myocardial contractility after cardiopulmonary bypass versus cardioplegic arrest in an air-ejecting in vivo heart model

AU - Addetia, A. M G

AU - Lichtenstein, S. V.

AU - Ko, A. S.

AU - Sikkonen, M.

AU - Sainani, M.

AU - Salerno, Tomas

PY - 1986/6/11

Y1 - 1986/6/11

N2 - Cardiac function was assessed in a working in vivo canine heart preparation. Minute work and myocardial oxygen consumption (MV(O2)) were measured after a two-hour period of hypothermic hyperkalemic crystalloid cardioplegic arrest in one group of dogs (Group 1, N = 6) and in another group of dogs on cardiopulmonary bypass (CPB) alone (Group 2, N = 6). Results indicate that at an afterload of 50 cm H2O, minute work was the same in all hearts but MV(O2) was significantly higher in Group 1 hearts at all levels of preload. At higher afterloads, both minute work and MV(O2) were significantly greater in Group 1 hearts over the range of preloads tested. Ventricular compliance was decreased in Group 1 over the range of preloads studied. These results suggest that heart undergoing cardioplegia arrest had better left ventricular contractility than hearts undergoing CPB alone.

AB - Cardiac function was assessed in a working in vivo canine heart preparation. Minute work and myocardial oxygen consumption (MV(O2)) were measured after a two-hour period of hypothermic hyperkalemic crystalloid cardioplegic arrest in one group of dogs (Group 1, N = 6) and in another group of dogs on cardiopulmonary bypass (CPB) alone (Group 2, N = 6). Results indicate that at an afterload of 50 cm H2O, minute work was the same in all hearts but MV(O2) was significantly higher in Group 1 hearts at all levels of preload. At higher afterloads, both minute work and MV(O2) were significantly greater in Group 1 hearts over the range of preloads tested. Ventricular compliance was decreased in Group 1 over the range of preloads studied. These results suggest that heart undergoing cardioplegia arrest had better left ventricular contractility than hearts undergoing CPB alone.

UR - http://www.scopus.com/inward/record.url?scp=0022638224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022638224&partnerID=8YFLogxK

M3 - Article

C2 - 3954496

AN - SCOPUS:0022638224

VL - 41

SP - 260

EP - 264

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 3

ER -