Study of the diffusion of some emulsions in the human skin by pulsed photoacoustic spectroscopy

F. Lahjomri, N. Benamar, E. Chatri, R. M. Leblanc

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We previously used pulsed photoacoustic spectroscopy (PPAS) to quantify sunscreen diffusion into human skin, and suggested a methodology to evaluate the time and the depth diffusion profile. These results were obtained by the analysis of the photoacoustic maximum response signal Pmax decrease, the time delay tmax and the Fourier transform representation of the photoacoustic signal. In this study we present the results obtained for diffusion of four typical emulsions used in sunscreen compositions that show, for the first time, a particular behaviour for one of these emulsions due to a chemical reaction inside the skin during the diffusion process. This result provides a particularly interesting technique through the PPAS, to evaluate in situ the eventual chemical reactions that can occur during drug diffusion into human skin.

Original languageEnglish (US)
Pages (from-to)2729-2738
Number of pages10
JournalPhysics in Medicine and Biology
Volume48
Issue number16
DOIs
StatePublished - Aug 21 2003

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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