Study of apoptosis-related interactions in colorectal cancer

Himanshu Arora, Rehana Qureshi, Ma Rizvi, Sharad Shrivastava, Mordhwaj S. Parihar

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Abnormalities in apoptotic functions contribute to the pathogenesis of colorectal cancer. In this study, molecular interactions behind the apoptotic regulation have been explored. For this purpose, enrichment analysis was performed considering microRNAs (miRNAs) that putatively target TP53 and altered during colon cancer. This revealed gene associated with both TP53 and miRNAs. Further analysis showed that a significant molecular interaction between the shortlisted candidates (TP53, miR-143, KRAS, BCL2, and PLK1) exists. Mutation study was conducted to confirm the clinical relevance of candidates. It showed that the mutation extent does not significantly alter survival in patients thus making these candidates suitable as drug targets. Overall, we showed the importance of interactions between TP53, miR-143, KRAS, BCL2, and PLK1 with respect to colorectal cancer using bioinformatics approach.

Original languageEnglish (US)
Pages (from-to)14415-14425
Number of pages11
JournalTumor Biology
Volume37
Issue number11
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Keywords

  • Apoptosis
  • Colorectal cancer
  • miRNA
  • TP53

ASJC Scopus subject areas

  • Cancer Research

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