TY - JOUR
T1 - Studies on the pituitary responsiveness to luteinizing hormone-releasing hormone (lh-rh) in intact male rats of different ages
AU - Debeljuk, Luciano
AU - Arimura, Akira
AU - Schally, Andrew V.
PY - 1972/2
Y1 - 1972/2
N2 - The pituitary response to a punned porcine LH-RH was investigated in male rats of IS, 25, 30, 35, 45, 60, and 240 days of age. Significant amounts of LH were released after administration of LH-RH in all the ages studied. The maximal response was seen, however, between 35 and 45 days of age, the lowest being at 15 and 240 days of age. No evidence of pituitary LH depletion after LH-RH was observed in any of the groups studied. LH-RH elicited a significant FSH release at 25, 30, 35, and 45 days of age. No significant FSH release was observed at 15, 60, and 240 days of age. The maximal response in terms of FSH release was recorded between 25 and 35 days of age. No apparent pituitary FSH depletion could be seen after LH-RH administration in any of the groups studied.
AB - The pituitary response to a punned porcine LH-RH was investigated in male rats of IS, 25, 30, 35, 45, 60, and 240 days of age. Significant amounts of LH were released after administration of LH-RH in all the ages studied. The maximal response was seen, however, between 35 and 45 days of age, the lowest being at 15 and 240 days of age. No evidence of pituitary LH depletion after LH-RH was observed in any of the groups studied. LH-RH elicited a significant FSH release at 25, 30, 35, and 45 days of age. No significant FSH release was observed at 15, 60, and 240 days of age. The maximal response in terms of FSH release was recorded between 25 and 35 days of age. No apparent pituitary FSH depletion could be seen after LH-RH administration in any of the groups studied.
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U2 - 10.1210/endo-90-2-585
DO - 10.1210/endo-90-2-585
M3 - Article
C2 - 4550537
AN - SCOPUS:0015295292
VL - 90
SP - 585
EP - 588
JO - Endocrinology
JF - Endocrinology
SN - 0013-7227
IS - 2
ER -