Studies on the iodination of LH-RH and the biological and immunological activities of the products

P. Piyachaturawata, E. Pedroza, W. Y. Huang, A. Arimura, A. V. Schally

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Synthetic LH-RH was iodinated by the modified chloramine-T or lactoperoxidase method, using 127INa or 125INa. The yields of the products, the LH releasing activities of the monoiodinated peptides as well as binding to pituitary membrane fractions were measured. The variation in yield in the four procedures used for iodination was a function of the amount of oxidizing agent. Monoiodinated products obtained by the different procedures possessed comparable LH-releasing activities as well as binding affinity to pituitary plasma membranes.

Original languageEnglish (US)
Pages (from-to)1309-1318
Number of pages10
JournalLife Sciences
Volume26
Issue number16
DOIs
StatePublished - Apr 21 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Studies on the iodination of LH-RH and the biological and immunological activities of the products'. Together they form a unique fingerprint.

  • Cite this