Studies of sarcolemmal integrity in myopathic muscle

W. G. Bradley, J. J. Fulthorpe

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Studies of sarcolemmal integrity with extracellular Procion Yellow gave evidence of structural defects in a high percentage of muscle fibers in Duchenne dystrophy and in vitamin E-deficiency myopathy in the guinea pig. The dye entered fibers in these conditions more often than in controls. Myofibrillary clumping occurred in the region of major penetration of the dye. It seems likely that sarcolemmal defects occur in vivo in these conditions, allowing the entry of high concentrations of calcium into the sarcoplasm with consequent fiber damage. The biochemical basis of these sarcolemmal defects remains to be elucidated. Our procedure for biopsy of the vastus medialis muscle may prove useful in preparing a limb muscle for in vitro physiologic studies.

Original languageEnglish (US)
Pages (from-to)670-677
Number of pages8
Issue number7
StatePublished - Jul 1978
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Studies of sarcolemmal integrity in myopathic muscle'. Together they form a unique fingerprint.

Cite this