Studies of controlled reperfusion after ischemia. VII. High oxygen requirements of dyskinetic cardiac muscle

B. S. Allen, Eliot Rosenkranz, G. D. Buckberg

Research output: Contribution to journalArticle

Abstract

This study assess the regional oxygen requirements of muscle segments that are beating and working, beating and empty, arrested and decompressed, and nonischemic that move dyskinetically. Regional oxygen demands were evaluated by producing a dyskinetic segment by infusing regional cardioplegia solution through a left anterior descending coronary artery catheter with and without extracorporeal circulation. The results show that the O2 demands of the perfused dyskinetic cardiac muscle segment (4 to 8 ml/100 gm/min) are approximately 55% of the contracting (beating, working) segment (7 to 12 ml/100 gm/min) and are fivefold more than when the same muscle segment is arrested and decompressed by total vented bypass (0.8 to 1.2 ml/100 gm/min). Additional studies showed that ischemia for 2 hours (left anterior descending coronary artery ligation) produced severe dyskinesia (-24% control systolic shortening), which failed to recover after reperfusion with the heart in the beating, working state. In contrast, lowering O2 demands by reperfusion during bypass restored occasional contractile function as a consequence of left ventricular decompression. Dyskinetic muscle segments have a high oxygen requirement that may affect their capacity to be salvaged if reperfusion is conducted without left ventricular decompression. These observations (1) suggest that the value of revascularization in the working heart (i.e., streptokinase with or without angioplasty) may be limited unless the left ventricle is decompressed during reperfusion and (2) provide an explanation for the delayed recovery of mechanical function in hearts reperfused surgically with normal blood during cardiopulmonary bypass.

Original languageEnglish (US)
Pages (from-to)543-552
Number of pages10
JournalJournal of Thoracic and Cardiovascular Surgery
Volume92
Issue number3 II
StatePublished - Jan 1 1986
Externally publishedYes

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Reperfusion
Myocardium
Ischemia
Oxygen
Decompression
Muscles
Coronary Vessels
Induced Heart Arrest
Streptokinase
Extracorporeal Circulation
Recovery of Function
Dyskinesias
Cardiopulmonary Bypass
Angioplasty
Heart Ventricles
Ligation
Catheters

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Studies of controlled reperfusion after ischemia. VII. High oxygen requirements of dyskinetic cardiac muscle. / Allen, B. S.; Rosenkranz, Eliot; Buckberg, G. D.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 92, No. 3 II, 01.01.1986, p. 543-552.

Research output: Contribution to journalArticle

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