Studies in the radiobiology of osteoradionecrosis and their clinical significance

Robert E. Marx, Robert P. Johnson

Research output: Contribution to journalArticlepeer-review

470 Scopus citations


The radiobiology of osteoradionecrosis is a complex of cellular death and cellular functional impairments from radiation energy transfers. Four studies of irradiated patients and a data base from 536 patients with osteoradionecrosis revealed separate pathophysiologic conditions for osteoradionecrosis induced by early trauma, osteoradionecrosis induced by late trauma, and spontaneous osteoradionecrosis. A large body of data suggested useful clinical guidelines for the management of irradiated patients. The guidelines, in part, include a recommendation for deferring radiation treatment for 21 days after tissue wounding, if possible; a relative contraindication to wounding tissue during a radiation course; a recommendation for the use of hyperbaric oxygen before wounding; and a strong recommendation to provide comprehensive dental care to the irradiated patient.

Original languageEnglish (US)
Pages (from-to)379-390
Number of pages12
JournalOral Surgery, Oral Medicine, Oral Pathology
Issue number4
StatePublished - Oct 1987

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dentistry(all)


Dive into the research topics of 'Studies in the radiobiology of osteoradionecrosis and their clinical significance'. Together they form a unique fingerprint.

Cite this