Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence

H. Matsuo, Y. Baba, R. M.G. Nair, A. Arimura, A. V. Schally

Research output: Contribution to journalArticle

972 Scopus citations

Abstract

The complete amino acid sequence of porcine LH- and FSH- releasing hormone has been provisionally determined by the use on a micro-scale of the combined Edman-dansyl procedure coupled with the selective tritiation method for C-terminal analysis. These procedures were used directly on the digestion products of LH-RH with chymotrypsin and thermolysin, without separation of the fragments. Additional data were provided by high resolution mass spectral fragmentation of LH-RH. On the basis of these results, we propose the following decapeptide sequence for LH-RH: (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.

Original languageEnglish (US)
Pages (from-to)1334-1339
Number of pages6
JournalBiochemical and biophysical research communications
Volume43
Issue number6
DOIs
StatePublished - Jun 18 1971
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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