Structure of human Vitronectin C-terminal domain and interaction with Yersinia pestis outer membrane protein Ail

Kyungsoo Shin, Bernhard C. Lechtenberg, Lynn M. Fujimoto, Yong Yao, Sara Schesser Bartra, Gregory V. Plano, Francesca M. Marassi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Vitronectin (Vn) is a major component of blood that controls many processes central to human biology. It is a drug target and a key factor in cell and tissue engineering applications, but despite long-standing efforts, little is known about the molecular basis for its functions. Here, we define the domain organization of Vn, report the crystal structure of its carboxyl-terminal domain, and show that it harbors the binding site for the Yersinia pestis outer membrane protein Ail, which recruits Vn to the bacterial cell surface to evade human host defenses. Vn forms a single four-bladed β/α-propeller that serves as a hub for multiple functions. The structure explains key features of native Vn and provides a blueprint for understanding and targeting this essential human protein.

Original languageEnglish (US)
Article numbereaax5068
JournalScience Advances
Volume5
Issue number9
DOIs
StatePublished - Sep 11 2019

ASJC Scopus subject areas

  • General

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