Structure of a gap junction gene: Rat connexin-32

Todd Miller, Gerhard Dahl, Rudolf Werner

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

A genomic clone for the rat liver gap junction protein (connexin-32) was isolated and characterized by restriction enzyme mapping and sequence analysis. While the complete coding sequence is contained within one uninterrupted block, the 5′-untranslated region of the transcript contains a 6.1 kb intron. Both S1 nuclease protection and primer extension assays indicate multiple transcription start sites. Sequences homologous to cAMP response elements are found near the transcription start sites and within the 3′-end of the intron.

Original languageEnglish (US)
Pages (from-to)455-464
Number of pages10
JournalBioscience reports
Volume8
Issue number5
DOIs
StatePublished - Oct 1 1988

Keywords

  • connexin
  • gap junction
  • gene structure

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)

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