Abstract
A genomic clone for the rat liver gap junction protein (connexin-32) was isolated and characterized by restriction enzyme mapping and sequence analysis. While the complete coding sequence is contained within one uninterrupted block, the 5′-untranslated region of the transcript contains a 6.1 kb intron. Both S1 nuclease protection and primer extension assays indicate multiple transcription start sites. Sequences homologous to cAMP response elements are found near the transcription start sites and within the 3′-end of the intron.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 455-464 |
| Number of pages | 10 |
| Journal | Bioscience reports |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1 1988 |
Keywords
- connexin
- gap junction
- gene structure
ASJC Scopus subject areas
- Cell Biology
- Biochemistry, Genetics and Molecular Biology(all)
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Miller, T., Dahl, G., & Werner, R. (1988). Structure of a gap junction gene: Rat connexin-32. Bioscience reports, 8(5), 455-464. https://doi.org/10.1007/BF01121644