Abstract
A genomic clone for the rat liver gap junction protein (connexin-32) was isolated and characterized by restriction enzyme mapping and sequence analysis. While the complete coding sequence is contained within one uninterrupted block, the 5′-untranslated region of the transcript contains a 6.1 kb intron. Both S1 nuclease protection and primer extension assays indicate multiple transcription start sites. Sequences homologous to cAMP response elements are found near the transcription start sites and within the 3′-end of the intron.
Original language | English (US) |
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Pages (from-to) | 455-464 |
Number of pages | 10 |
Journal | Bioscience reports |
Volume | 8 |
Issue number | 5 |
DOIs | |
State | Published - Oct 1 1988 |
Keywords
- connexin
- gap junction
- gene structure
ASJC Scopus subject areas
- Cell Biology
- Biochemistry, Genetics and Molecular Biology(all)