Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters.

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Abstract

After a brief review of a number of issues related to the enzymatic hydrolysis of carboxylic esters, scuh as interspecies variability, mechanism, stereospecificity, and activation energy, and after and overview of relevant aspects related to the quantitative modeling of steric effects, the results of a recently developed quantitative structure-metabolism relationship model are discussed. They were obtained for in vitro human blood enzymatic hydrolysis of noncongener esters by introduction of the inaccessible solid angle as a novel measure of steric hindrance.

Original languageEnglish
Pages (from-to)101-111
Number of pages11
JournalMini reviews in medicinal chemistry
Volume1
Issue number1
StatePublished - May 1 2001
Externally publishedYes

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Enzymatic hydrolysis
Metabolism
Esters
Hydrolysis
Blood
Activation energy
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

Cite this

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