Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters.

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

After a brief review of a number of issues related to the enzymatic hydrolysis of carboxylic esters, scuh as interspecies variability, mechanism, stereospecificity, and activation energy, and after and overview of relevant aspects related to the quantitative modeling of steric effects, the results of a recently developed quantitative structure-metabolism relationship model are discussed. They were obtained for in vitro human blood enzymatic hydrolysis of noncongener esters by introduction of the inaccessible solid angle as a novel measure of steric hindrance.

Original languageEnglish (US)
Pages (from-to)101-111
Number of pages11
JournalMini reviews in medicinal chemistry
Volume1
Issue number1
DOIs
StatePublished - May 2001

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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