Abstract
After a brief review of a number of issues related to the enzymatic hydrolysis of carboxylic esters, scuh as interspecies variability, mechanism, stereospecificity, and activation energy, and after and overview of relevant aspects related to the quantitative modeling of steric effects, the results of a recently developed quantitative structure-metabolism relationship model are discussed. They were obtained for in vitro human blood enzymatic hydrolysis of noncongener esters by introduction of the inaccessible solid angle as a novel measure of steric hindrance.
| Original language | English |
|---|---|
| Pages (from-to) | 101-111 |
| Number of pages | 11 |
| Journal | Mini reviews in medicinal chemistry |
| Volume | 1 |
| Issue number | 1 |
| State | Published - May 1 2001 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
- Chemistry(all)
- Pharmacology
Cite this
Structure-metabolism relationships : steric effects and the enzymatic hydrolysis of carboxylic esters. / Buchwald, P.
In: Mini reviews in medicinal chemistry, Vol. 1, No. 1, 01.05.2001, p. 101-111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structure-metabolism relationships
T2 - steric effects and the enzymatic hydrolysis of carboxylic esters.
AU - Buchwald, P.
PY - 2001/5/1
Y1 - 2001/5/1
N2 - After a brief review of a number of issues related to the enzymatic hydrolysis of carboxylic esters, scuh as interspecies variability, mechanism, stereospecificity, and activation energy, and after and overview of relevant aspects related to the quantitative modeling of steric effects, the results of a recently developed quantitative structure-metabolism relationship model are discussed. They were obtained for in vitro human blood enzymatic hydrolysis of noncongener esters by introduction of the inaccessible solid angle as a novel measure of steric hindrance.
AB - After a brief review of a number of issues related to the enzymatic hydrolysis of carboxylic esters, scuh as interspecies variability, mechanism, stereospecificity, and activation energy, and after and overview of relevant aspects related to the quantitative modeling of steric effects, the results of a recently developed quantitative structure-metabolism relationship model are discussed. They were obtained for in vitro human blood enzymatic hydrolysis of noncongener esters by introduction of the inaccessible solid angle as a novel measure of steric hindrance.
UR - http://www.scopus.com/inward/record.url?scp=0035352673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035352673&partnerID=8YFLogxK
M3 - Article
C2 - 12369995
AN - SCOPUS:0035352673
VL - 1
SP - 101
EP - 111
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
SN - 1389-5575
IS - 1
ER -