Structure and Function of the Human Insula

Lucina Q Uddin, Jason Nomi, Benjamin Hébert-Seropian, Jimmy Ghaziri, Olivier Boucher

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

Summary:The insular cortex, or "Island of Reil," is hidden deep within the lateral sulcus of the brain. Subdivisions within the insula have been identified on the basis of cytoarchitectonics, sulcal landmarks, and connectivity. Depending on the parcellation technique used, the insula can be divided into anywhere between 2 and 13 distinct subdivisions. The insula subserves a wide variety of functions in humans ranging from sensory and affective processing to high-level cognition. Here, we provide a concise summary of known structural and functional features of the human insular cortex with a focus on lesion case studies and recent neuroimaging evidence for considerable functional heterogeneity of this brain region.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalJournal of Clinical Neurophysiology
Volume34
Issue number4
DOIs
StatePublished - Jul 1 2017

Keywords

  • Functional connectivity
  • Island of Reil
  • Meta-analysis
  • Parcellation

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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