Structure and function of human perforin

Mathias G Lichtenheld, K. J. Olsen, P. Lu, D. M. Lowrey, A. Hameed, H. Hengartner, E. R. Podack

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267 Citations (Scopus)

Abstract

Perforin (P1) is a cytolytic protein with similarity to complement component C9. P1 has been described as a unique component of murine cytolytic T-cell and rat natural killer cell granules. Previous studies indicated that human granules and P1 differed from murine granules and P1 in that they appeared to be cytolytically less active and lacked the haemolytic activity characteristic of P1. It has been suggested that P1, like C9, is under the control of the homologous restriction factor. Here we determine the primary structure of human P1, re-examine its functional properties, and address the question of homologous restriction.

Original languageEnglish
Pages (from-to)448-451
Number of pages4
JournalNature
Volume335
Issue number6189
StatePublished - Jan 1 1988

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Perforin
Complement C9
Natural Killer Cells
T-Lymphocytes
Proteins

ASJC Scopus subject areas

  • General

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Lichtenheld, M. G., Olsen, K. J., Lu, P., Lowrey, D. M., Hameed, A., Hengartner, H., & Podack, E. R. (1988). Structure and function of human perforin. Nature, 335(6189), 448-451.

Structure and function of human perforin. / Lichtenheld, Mathias G; Olsen, K. J.; Lu, P.; Lowrey, D. M.; Hameed, A.; Hengartner, H.; Podack, E. R.

In: Nature, Vol. 335, No. 6189, 01.01.1988, p. 448-451.

Research output: Contribution to journalArticle

Lichtenheld, MG, Olsen, KJ, Lu, P, Lowrey, DM, Hameed, A, Hengartner, H & Podack, ER 1988, 'Structure and function of human perforin', Nature, vol. 335, no. 6189, pp. 448-451.
Lichtenheld MG, Olsen KJ, Lu P, Lowrey DM, Hameed A, Hengartner H et al. Structure and function of human perforin. Nature. 1988 Jan 1;335(6189):448-451.
Lichtenheld, Mathias G ; Olsen, K. J. ; Lu, P. ; Lowrey, D. M. ; Hameed, A. ; Hengartner, H. ; Podack, E. R. / Structure and function of human perforin. In: Nature. 1988 ; Vol. 335, No. 6189. pp. 448-451.
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