Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide

Barry D. Nelkin, Kenneth I. Rosenfeld, Andrée de Bustros, Susan S. Leong, Bernard A. Roos, Stephen B. Baylin

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line. DNA sequences of their cloned cDNAs, and genomic restriction mapping, indicate that both mRNAs probably originate from a single gene; the separate mRNAs are derived by alternative processing. The calcitonin gene is expressed in 10 of 10 examined culture lines of human lung cancer; most of these lines express a higher ratio of CGRP to CT specific mRNA than does the medullary thyroid carcinoma cell line.

Original languageEnglish (US)
Pages (from-to)648-655
Number of pages8
JournalBiochemical and biophysical research communications
Volume123
Issue number2
DOIs
StatePublished - Sep 17 1984

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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