Structure-activity relationships of peroxide-based artemisinin antimalarials

Mitchell A. Avery, Graham McLean, Geoff Edwards, Arba L Ager

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

The biosynthesis of artemisinin3 is of interest in that it provides clues to the chemical synthesis of artemisinin from its more abundant precursor in A. annua, artemisinic acid 2. Conjugate reduction of the acrylate double bond of 2 followed by singlet oxygenation leads, after acidification, to the production of artemisinin.4 While percentages as high as 2.6% have been quoted for isolation of artemisinic acid,5 anecdote suggests that drying of plant material must occur in the dark. Material dried in the sun contains very little 2.

Original languageEnglish (US)
Title of host publicationBiologically Active Natural Products
Subtitle of host publicationPharmaceuticals
PublisherCRC Press
Pages115-126
Number of pages12
ISBN (Electronic)9781420048650
ISBN (Print)9780849318870
DOIs
StatePublished - Jan 1 1999

Fingerprint

artemisinin
antimalarials
Peroxides
Antimalarials
structure-activity relationships
Structure-Activity Relationship
peroxides
Anecdotes
Oxygenation
Acidification
acids
Biosynthesis
Solar System
Sun
acidification
Drying
drying
biosynthesis
synthesis
artemisinine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Avery, M. A., McLean, G., Edwards, G., & Ager, A. L. (1999). Structure-activity relationships of peroxide-based artemisinin antimalarials. In Biologically Active Natural Products: Pharmaceuticals (pp. 115-126). CRC Press. https://doi.org/10.1201/9781420048650

Structure-activity relationships of peroxide-based artemisinin antimalarials. / Avery, Mitchell A.; McLean, Graham; Edwards, Geoff; Ager, Arba L.

Biologically Active Natural Products: Pharmaceuticals. CRC Press, 1999. p. 115-126.

Research output: Chapter in Book/Report/Conference proceedingChapter

Avery, MA, McLean, G, Edwards, G & Ager, AL 1999, Structure-activity relationships of peroxide-based artemisinin antimalarials. in Biologically Active Natural Products: Pharmaceuticals. CRC Press, pp. 115-126. https://doi.org/10.1201/9781420048650
Avery MA, McLean G, Edwards G, Ager AL. Structure-activity relationships of peroxide-based artemisinin antimalarials. In Biologically Active Natural Products: Pharmaceuticals. CRC Press. 1999. p. 115-126 https://doi.org/10.1201/9781420048650
Avery, Mitchell A. ; McLean, Graham ; Edwards, Geoff ; Ager, Arba L. / Structure-activity relationships of peroxide-based artemisinin antimalarials. Biologically Active Natural Products: Pharmaceuticals. CRC Press, 1999. pp. 115-126
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