Structure-activity relationships of peroxide-based artemisinin antimalarials

Mitchell A. Avery, Graham McLean, Geoff Edwards, Arba Ager

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The biosynthesis of artemisinin3 is of interest in that it provides clues to the chemical synthesis of artemisinin from its more abundant precursor in A. annua, artemisinic acid 2. Conjugate reduction of the acrylate double bond of 2 followed by singlet oxygenation leads, after acidification, to the production of artemisinin.4 While percentages as high as 2.6% have been quoted for isolation of artemisinic acid,5 anecdote suggests that drying of plant material must occur in the dark. Material dried in the sun contains very little 2.

Original languageEnglish (US)
Title of host publicationBiologically Active Natural Products
Subtitle of host publicationPharmaceuticals
PublisherCRC Press
Pages115-126
Number of pages12
ISBN (Electronic)9781420048650
ISBN (Print)9780849318870
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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