Structural studies on the chiral selector capacity of cyclodextrin derivatives.

Béla Tokés, László Ferencz, Peter Buchwald, Gabriella Donáth-Nagy, Szende Vancea, Nándor Sánta, Erika Lilla Kis

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Chromatographic separation of enantiomers to assure or enhance chiral purity is of considerable importance and can be achieved by the use of selectors of great structural variety. Cyclodextrins are an important and frequently used class, and they are multimodal selectors since multiple chiral interactions are possible by very different mechanisms. Here, the results of a preliminary examination on the possible value of computational molecular modeling approaches for the predictability of cyclodextrin selector effects for compounds that possess both geometrical and optical isomerism are presented. Interactions between various cyclodextrins and pyrethroic acids are modeled, interpreted, and compared to experimental capillary electrophoresis data.

Original languageEnglish (US)
Pages (from-to)1276-1282
Number of pages7
JournalJournal of biochemical and biophysical methods
Volume70
Issue number6
DOIs
StatePublished - Apr 24 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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