Structural MRI of carotid artery atherosclerotic lesion burden and characterization of hemispheric cerebral blood flow before and after carotid endarterectomy

C. E. Jones, Ronald L. Wolf, J. A. Detre, B. Das, P. K. Saha, J. Wang, Y. Zhang, H. K. Song, A. C. Wright, E. M. Mohler, R. M. Fairman, E. L. Zager, Omaida C Velazquez, M. A. Golden, J. P. Carpenter, F. W. Wehrli

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Collateral circulation plays a major role in maintaining cerebral blood flow (CBF) in patients with internal carotid artery (ICA) stenosis. CBF can remain normal despite severe ICA stenosis, making the benefit of carotid endarterectomy (CEA) or stenting difficult to assess. Before and after surgery, we assessed CBF supplied through the ipsilateral (stenotic) or contralateral ICA individually with a novel hemisphere-selective arterial spin-labeling (ASL) perfusion MR technique. We further explored the relationship between CBF and ICA obstruction ratio (OR) acquired with a multislice black-blood imaging sequence. For patients with unilateral ICA stenosis (n = 19), conventional bilateral labeling did not reveal interhemispheric differences. With unilateral labeling, CBF in the middle cerebral artery (MCA) territory on the surgical side from the ipsilateral supply (53.7 ± 3.3 ml/100 g/min) was lower than CBF in the contralateral MCA territory from the contralateral supply (58.5 ± 2.7 ml/100 g/min), although not statistically significant (p = 0.09). The ipsilateral MCA territory received significant (p = 0.02) contralateral supply (7.0 ± 2.7 ml/100 g/min), while ipsilateral supply to the contralateral side was not reciprocated. After surgery (n = 11), ipsilateral supply to the MCA territory increased from 57.3 ± 5.7 to 67.3 ± 5.4 ml/100 g/min (p = 0.03), and contralateral supply to the ipsilateral MCA territory decreased. The best predictor of increased CBF on the side of surgery was normalized presurgical ipsilateral supply (r2 = 0.62, p = 0.004). OR was less predictive of change, although the change in normalized contralateral supply was negatively correlated with ORexcess (=ORipsilateral - ORcontralateral) (r2 = 0.58, p = 0.006). The results demonstrate the effect of carotid artery stenosis on blood supply to the cerebral hemispheres, as well as the relative role of collateral pathways before surgery and redistribution of blood flow through these pathways after surgery. Unilateral ASL may better predict hemodynamic surgical outcome (measured by improved perfusion) than ICA OR.

Original languageEnglish
Pages (from-to)198-208
Number of pages11
JournalNMR in Biomedicine
Volume19
Issue number2
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Carotid Endarterectomy
Carotid Arteries
Magnetic resonance imaging
Blood
Middle Cerebral Artery
Carotid Stenosis
Surgery
Internal Carotid Artery
Labeling
Perfusion
Collateral Circulation
Cerebrum
Hemodynamics

Keywords

  • Arterial spin labeling
  • Carotid artery disease
  • Cerebal hypoperfusion
  • MRI
  • Perfusion imaging
  • Stroke

ASJC Scopus subject areas

  • Spectroscopy
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Structural MRI of carotid artery atherosclerotic lesion burden and characterization of hemispheric cerebral blood flow before and after carotid endarterectomy. / Jones, C. E.; Wolf, Ronald L.; Detre, J. A.; Das, B.; Saha, P. K.; Wang, J.; Zhang, Y.; Song, H. K.; Wright, A. C.; Mohler, E. M.; Fairman, R. M.; Zager, E. L.; Velazquez, Omaida C; Golden, M. A.; Carpenter, J. P.; Wehrli, F. W.

In: NMR in Biomedicine, Vol. 19, No. 2, 01.04.2006, p. 198-208.

Research output: Contribution to journalArticle

Jones, CE, Wolf, RL, Detre, JA, Das, B, Saha, PK, Wang, J, Zhang, Y, Song, HK, Wright, AC, Mohler, EM, Fairman, RM, Zager, EL, Velazquez, OC, Golden, MA, Carpenter, JP & Wehrli, FW 2006, 'Structural MRI of carotid artery atherosclerotic lesion burden and characterization of hemispheric cerebral blood flow before and after carotid endarterectomy', NMR in Biomedicine, vol. 19, no. 2, pp. 198-208. https://doi.org/10.1002/nbm.1017
Jones, C. E. ; Wolf, Ronald L. ; Detre, J. A. ; Das, B. ; Saha, P. K. ; Wang, J. ; Zhang, Y. ; Song, H. K. ; Wright, A. C. ; Mohler, E. M. ; Fairman, R. M. ; Zager, E. L. ; Velazquez, Omaida C ; Golden, M. A. ; Carpenter, J. P. ; Wehrli, F. W. / Structural MRI of carotid artery atherosclerotic lesion burden and characterization of hemispheric cerebral blood flow before and after carotid endarterectomy. In: NMR in Biomedicine. 2006 ; Vol. 19, No. 2. pp. 198-208.
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AU - Jones, C. E.

AU - Wolf, Ronald L.

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AU - Saha, P. K.

AU - Wang, J.

AU - Zhang, Y.

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AU - Wright, A. C.

AU - Mohler, E. M.

AU - Fairman, R. M.

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