Structural MRI Changes of the Brain in Depression

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33 Scopus citations


For many years, investigators have been trying to identify the neuroanatomical structures responsible for the development of neuropsychiatry disorders, specifically depression and schizophreniform disorders. The available data were based on observations made in neurological patients who developed a psychiatric comorbid disorder following the neurologic insult. With the advances in high-resolution magnetic resonance imaging and functional neuroimaging studies, we have witnessed in the last decade a wealth of new data that identify structural neuroimaging changes in mesial temporal structures, prefrontal cortex and basal ganglia in major depressive disorders. The purpose of this article is to briefly review the publshed data on neuroanatomical structural changes associated with major depressive and bipolar disorders.

Original languageEnglish (US)
Pages (from-to)46-52
Number of pages7
JournalClinical EEG and Neuroscience
Issue number1
StatePublished - Jan 2004
Externally publishedYes


  • Amygdala
  • Basal Ganglia
  • Hippocampal Atrophy
  • Post-stroke Depression
  • Prefrontal Cortex
  • Resonance Magnetic Imaging (MRI)
  • Volumetric Measurements

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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