Structural modifications in chronic microwire electrodes for cortical neuroprosthetics: A case study

Justin C. Sanchez, Nicolas Alba, Toshikazu Nishida, Christopher Batich, Paul R. Carney

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Long-term viability of chronic invasive neural probes is a necessary condition for extracting robust control signals directly from neural tissue. Although immune/tissue response is a leading factor in the degradation of single neuron recording, we investigate a second component of signal degradation connected to the structural changes associated with microwire electrodes chronically exposed to extracelluar environments in vivo. Scanning electron microscopy is used to assess the surface modifications to the electrodes after an implantation duration of four weeks in rats. The electrode developed a smooth fracture surface, a reduction of the metal diameter, and pitting in the insulation of the electrode structure. Over the duration of implantation, recording properties of the electrode were marked by a reduction in the peak-to-peak amplitude in neuronal firing.

Original languageEnglish (US)
Article number1642773
Pages (from-to)217-221
Number of pages5
JournalIEEE Transactions on Neural Systems and Rehabilitation Engineering
Issue number2
StatePublished - Jun 1 2006


  • Action potential
  • Chronic
  • Materials
  • Microwire electrode
  • Neural recording
  • Structural

ASJC Scopus subject areas

  • Rehabilitation
  • Biophysics
  • Bioengineering
  • Health Professions(all)


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