Abstract
Long-term viability of chronic invasive neural probes is a necessary condition for extracting robust control signals directly from neural tissue. Although immune/tissue response is a leading factor in the degradation of single neuron recording, we investigate a second component of signal degradation connected to the structural changes associated with microwire electrodes chronically exposed to extracelluar environments in vivo. Scanning electron microscopy is used to assess the surface modifications to the electrodes after an implantation duration of four weeks in rats. The electrode developed a smooth fracture surface, a reduction of the metal diameter, and pitting in the insulation of the electrode structure. Over the duration of implantation, recording properties of the electrode were marked by a reduction in the peak-to-peak amplitude in neuronal firing.
| Original language | English |
|---|---|
| Article number | 1642773 |
| Pages (from-to) | 217-221 |
| Number of pages | 5 |
| Journal | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2006 |
| Externally published | Yes |
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Keywords
- Action potential
- Chronic
- Materials
- Microwire electrode
- Neural recording
- Structural
ASJC Scopus subject areas
- Rehabilitation
- Biophysics
- Bioengineering
- Health Professions(all)
Cite this
Structural modifications in chronic microwire electrodes for cortical neuroprosthetics : A case study. / Sanchez, Justin C.; Alba, Nicolas; Nishida, Toshikazu; Batich, Christopher; Carney, Paul R.
In: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 14, No. 2, 1642773, 01.06.2006, p. 217-221.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structural modifications in chronic microwire electrodes for cortical neuroprosthetics
T2 - A case study
AU - Sanchez, Justin C.
AU - Alba, Nicolas
AU - Nishida, Toshikazu
AU - Batich, Christopher
AU - Carney, Paul R.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Long-term viability of chronic invasive neural probes is a necessary condition for extracting robust control signals directly from neural tissue. Although immune/tissue response is a leading factor in the degradation of single neuron recording, we investigate a second component of signal degradation connected to the structural changes associated with microwire electrodes chronically exposed to extracelluar environments in vivo. Scanning electron microscopy is used to assess the surface modifications to the electrodes after an implantation duration of four weeks in rats. The electrode developed a smooth fracture surface, a reduction of the metal diameter, and pitting in the insulation of the electrode structure. Over the duration of implantation, recording properties of the electrode were marked by a reduction in the peak-to-peak amplitude in neuronal firing.
AB - Long-term viability of chronic invasive neural probes is a necessary condition for extracting robust control signals directly from neural tissue. Although immune/tissue response is a leading factor in the degradation of single neuron recording, we investigate a second component of signal degradation connected to the structural changes associated with microwire electrodes chronically exposed to extracelluar environments in vivo. Scanning electron microscopy is used to assess the surface modifications to the electrodes after an implantation duration of four weeks in rats. The electrode developed a smooth fracture surface, a reduction of the metal diameter, and pitting in the insulation of the electrode structure. Over the duration of implantation, recording properties of the electrode were marked by a reduction in the peak-to-peak amplitude in neuronal firing.
KW - Action potential
KW - Chronic
KW - Materials
KW - Microwire electrode
KW - Neural recording
KW - Structural
UR - http://www.scopus.com/inward/record.url?scp=33746467189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33746467189&partnerID=8YFLogxK
U2 - 10.1109/TNSRE.2006.875581
DO - 10.1109/TNSRE.2006.875581
M3 - Article
C2 - 16792298
AN - SCOPUS:33746467189
VL - 14
SP - 217
EP - 221
JO - IEEE Transactions on Neural Systems and Rehabilitation Engineering
JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering
SN - 1534-4320
IS - 2
M1 - 1642773
ER -