TY - JOUR
T1 - Structural-functional dissociation in presumed ethambutol optic neuropathy
AU - Masvidal, Daniel
AU - Parrish, Richard K.
AU - Lam, Byron L.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/12
Y1 - 2010/12
N2 - A 55-year-old man with pulmonary Mycobacterium avium intracellulare infection developed decreased vision to 3/200 in the right eye, and 20/200 in the left eye, 11 months after starting ethambutol, rifampin, and isoniazid. A diagnosis of presumed ethambutol optic neuropathy was made, and the medications were discontinued. Visual acuity gradually improved to 20/30 and 20/70 over a period of 34 months. Despite improved central vision and visual field, the patient developed progressive bilateral optic disc cupping, disc pallor, and diffuse nerve fiber layer loss on optical coherence tomography. The observed optic nerve head structural changes in this patient did not correlate with the markedly improved visual function. Visual improvement may occur in ethambutol optic neuropathy despite progressive structural changes.
AB - A 55-year-old man with pulmonary Mycobacterium avium intracellulare infection developed decreased vision to 3/200 in the right eye, and 20/200 in the left eye, 11 months after starting ethambutol, rifampin, and isoniazid. A diagnosis of presumed ethambutol optic neuropathy was made, and the medications were discontinued. Visual acuity gradually improved to 20/30 and 20/70 over a period of 34 months. Despite improved central vision and visual field, the patient developed progressive bilateral optic disc cupping, disc pallor, and diffuse nerve fiber layer loss on optical coherence tomography. The observed optic nerve head structural changes in this patient did not correlate with the markedly improved visual function. Visual improvement may occur in ethambutol optic neuropathy despite progressive structural changes.
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U2 - 10.1097/WNO.0b013e3181e08ecb
DO - 10.1097/WNO.0b013e3181e08ecb
M3 - Article
C2 - 20592624
AN - SCOPUS:78650517655
VL - 30
SP - 305
EP - 310
JO - Journal of Neuro-Ophthalmology
JF - Journal of Neuro-Ophthalmology
SN - 1070-8022
IS - 4
ER -