Structural features of two T-cell-specific genes that suggest a potential role in HTLV-I-associated pathology

R. Patarca, M. A. Fletcher, H. Cantor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Rpt-1 gene product is an intranuclear protein expressed by CD4+ T-cells, which may regulate expression of the interleukin-2 receptor. Structural analysis of Rpt-1 reveals structural motifs that are shared by a group of transcriptional regulatory proteins with oncogenic potential. We suggest that altered expression of Rpt-1 may be associated with HTLV-I-dependent T-cell leukemias.

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalAIDS Research and Human Retroviruses
Volume9
Issue number2
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Human T-lymphotropic virus 1
Pathology
T-Lymphocytes
T-Cell Leukemia
Interleukin-2 Receptors
Genes
Proteins

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Structural features of two T-cell-specific genes that suggest a potential role in HTLV-I-associated pathology. / Patarca, R.; Fletcher, M. A.; Cantor, H.

In: AIDS Research and Human Retroviruses, Vol. 9, No. 2, 01.01.1993, p. 105-107.

Research output: Contribution to journalArticle

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