@article{55eb708d30d04b28b90168e607504fc9,
title = "Structural and functional characterization of human chromosome 13q14 and its potential tumor suppressor genes",
abstract = "Works on chromosome 13 mapping supported by the Russian program Human Genome are reviewed. Emphasis is placed on studies of region 13q14.3, which is often lost in some human tumors and potentially contains tumor suppressor genes (TSG). A strategy of TSG search is described. As the resolution of genome analysis improved, a minimal overlap of genetic loss in B-cell chronic lymphocytic leukemia (B-CLL) was established for chromosome 13. A map of expressed sequences was constructed for the region containing the overlap, and candidate TSG of chromosome 13q14 were identified. The candidate genes were analyzed both structurally and functionally, and their possible role in tumorigenesis was considered. Assuming haploinsufficiency as a genetic mechanism controlling B-CLL, a new strategy was proposed for mutation screening aimed at identifying potential TSG of region 13q14.",
keywords = "13q14, B-cell chronic lymphocytic leukemia, Chromosome 13, Human genome, Tumor suppressor genes",
author = "Baranova, {A. V.} and Ivanov, {D. V.} and Tyazhelova, {T. V.} and Yankovsky, {N. K.}",
note = "Funding Information: We are grateful to S. Einhorn, E. Zabarovsky (Karo-linska Hospital, Stockholm, Sweden), C. Buys (Groning University, the Netherlands), H. Lerah (Max-Planck Institute, Berlin, Germany), I. Edelman, S. Kalachikov (Columbia University, New York, United States), and to all Russian colleagues who participated in work on the project Chromosome 13 Mapping and Sequencing. Grants from the Russian program Human Genome and the RF Ministry of Industry, Science, and Technology, along with the international recognition of the Russian program Human Genome, allowed us to get support from non-Russian organizations. This support was vital for our work at some periods, and included grants from the Energy Department of the United States and the Swedish Academy of Sciences, grants from HUGO for our participation in many conferences, reagents, materials, instruments, and the possibility of working in labs beyond Russia. Our current work is supported by the Russian Academy of Sciences (a grant to the Laboratory of Genome Analysis, Vavilov Institute of General Genetics) and by the Russian Foundation for Basic Research (project nos. 02-04-48849, 02-04-48352).",
year = "2004",
month = mar,
doi = "10.1023/B:MBIL.0000023730.61501.aa",
language = "English (US)",
volume = "38",
pages = "165--173",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "2",
}