Abstract
Works on chromosome 13 mapping supported by the Russian program Human Genome are reviewed. Emphasis is placed on studies of region 13q14.3, which is often lost in some human tumors and potentially contains tumor suppressor genes (TSG). A strategy of TSG search is described. As the resolution of genome analysis improved, a minimal overlap of genetic loss in B-cell chronic lymphocytic leukemia (B-CLL) was established for chromosome 13. A map of expressed sequences was constructed for the region containing the overlap, and candidate TSG of chromosome 13q14 were identified. The candidate genes were analyzed both structurally and functionally, and their possible role in tumorigenesis was considered. Assuming haploinsufficiency as a genetic mechanism controlling B-CLL, a new strategy was proposed for mutation screening aimed at identifying potential TSG of region 13q14.
| Original language | English |
|---|---|
| Pages (from-to) | 165-173 |
| Number of pages | 9 |
| Journal | Molecular Biology |
| Volume | 38 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2004 |
| Externally published | Yes |
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Keywords
- 13q14
- B-cell chronic lymphocytic leukemia
- Chromosome 13
- Human genome
- Tumor suppressor genes
ASJC Scopus subject areas
- Genetics
Cite this
Structural and functional characterization of human chromosome 13q14 and its potential tumor suppressor genes. / Baranova, A. V.; Ivanov, Dmitry V; Tyazhelova, T. V.; Yankovsky, N. K.
In: Molecular Biology, Vol. 38, No. 2, 01.03.2004, p. 165-173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structural and functional characterization of human chromosome 13q14 and its potential tumor suppressor genes
AU - Baranova, A. V.
AU - Ivanov, Dmitry V
AU - Tyazhelova, T. V.
AU - Yankovsky, N. K.
PY - 2004/3/1
Y1 - 2004/3/1
N2 - Works on chromosome 13 mapping supported by the Russian program Human Genome are reviewed. Emphasis is placed on studies of region 13q14.3, which is often lost in some human tumors and potentially contains tumor suppressor genes (TSG). A strategy of TSG search is described. As the resolution of genome analysis improved, a minimal overlap of genetic loss in B-cell chronic lymphocytic leukemia (B-CLL) was established for chromosome 13. A map of expressed sequences was constructed for the region containing the overlap, and candidate TSG of chromosome 13q14 were identified. The candidate genes were analyzed both structurally and functionally, and their possible role in tumorigenesis was considered. Assuming haploinsufficiency as a genetic mechanism controlling B-CLL, a new strategy was proposed for mutation screening aimed at identifying potential TSG of region 13q14.
AB - Works on chromosome 13 mapping supported by the Russian program Human Genome are reviewed. Emphasis is placed on studies of region 13q14.3, which is often lost in some human tumors and potentially contains tumor suppressor genes (TSG). A strategy of TSG search is described. As the resolution of genome analysis improved, a minimal overlap of genetic loss in B-cell chronic lymphocytic leukemia (B-CLL) was established for chromosome 13. A map of expressed sequences was constructed for the region containing the overlap, and candidate TSG of chromosome 13q14 were identified. The candidate genes were analyzed both structurally and functionally, and their possible role in tumorigenesis was considered. Assuming haploinsufficiency as a genetic mechanism controlling B-CLL, a new strategy was proposed for mutation screening aimed at identifying potential TSG of region 13q14.
KW - 13q14
KW - B-cell chronic lymphocytic leukemia
KW - Chromosome 13
KW - Human genome
KW - Tumor suppressor genes
UR - http://www.scopus.com/inward/record.url?scp=3542998094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3542998094&partnerID=8YFLogxK
U2 - 10.1023/B:MBIL.0000023730.61501.aa
DO - 10.1023/B:MBIL.0000023730.61501.aa
M3 - Article
AN - SCOPUS:3542998094
VL - 38
SP - 165
EP - 173
JO - Molecular Biology
JF - Molecular Biology
SN - 0026-8933
IS - 2
ER -