Structural and functional characterization of human chromosome 13q14 and its potential tumor suppressor genes

A. V. Baranova, Dmitry V Ivanov, T. V. Tyazhelova, N. K. Yankovsky

Research output: Contribution to journalArticle

Abstract

Works on chromosome 13 mapping supported by the Russian program Human Genome are reviewed. Emphasis is placed on studies of region 13q14.3, which is often lost in some human tumors and potentially contains tumor suppressor genes (TSG). A strategy of TSG search is described. As the resolution of genome analysis improved, a minimal overlap of genetic loss in B-cell chronic lymphocytic leukemia (B-CLL) was established for chromosome 13. A map of expressed sequences was constructed for the region containing the overlap, and candidate TSG of chromosome 13q14 were identified. The candidate genes were analyzed both structurally and functionally, and their possible role in tumorigenesis was considered. Assuming haploinsufficiency as a genetic mechanism controlling B-CLL, a new strategy was proposed for mutation screening aimed at identifying potential TSG of region 13q14.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalMolecular Biology
Volume38
Issue number2
DOIs
StatePublished - Mar 1 2004
Externally publishedYes

Fingerprint

Human Chromosomes
Tumor Suppressor Genes
Chromosomes, Human, Pair 13
B-Cell Chronic Lymphocytic Leukemia
Haploinsufficiency
Chromosome Mapping
Human Genome
Carcinogenesis
Chromosomes
Genome
Mutation
Genes
Neoplasms

Keywords

  • 13q14
  • B-cell chronic lymphocytic leukemia
  • Chromosome 13
  • Human genome
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Genetics

Cite this

Structural and functional characterization of human chromosome 13q14 and its potential tumor suppressor genes. / Baranova, A. V.; Ivanov, Dmitry V; Tyazhelova, T. V.; Yankovsky, N. K.

In: Molecular Biology, Vol. 38, No. 2, 01.03.2004, p. 165-173.

Research output: Contribution to journalArticle

Baranova, A. V. ; Ivanov, Dmitry V ; Tyazhelova, T. V. ; Yankovsky, N. K. / Structural and functional characterization of human chromosome 13q14 and its potential tumor suppressor genes. In: Molecular Biology. 2004 ; Vol. 38, No. 2. pp. 165-173.
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