Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography

Valdir A. Moisés, Ricardo L. Ferreira, Emília Nozawa, Rosemeire Takeuchi, Orlando F. Campos, José Lázaro De Andrade, Antonio Carlos C. Carvalho, Paulo J.F. Tucci

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective - To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. Methods - Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. Results - Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. Conclusion - Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalArquivos Brasileiros de Cardiologia
Volume75
Issue number2
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Doppler Echocardiography
Infarction
Myocardial Infarction
Dilatation
Pulmonary Valve
Ventricular Pressure
Heart Atria
Mitral Valve
Pulmonary Hypertension
Pulmonary Artery
Heart Ventricles
Ligation
Echocardiography
Wistar Rats
Coronary Vessels
Blood Pressure
Pressure
Sensitivity and Specificity
Lung

Keywords

  • Doppler echocardiogram
  • Myocardial infarct
  • Rat hearts

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography. / Moisés, Valdir A.; Ferreira, Ricardo L.; Nozawa, Emília; Takeuchi, Rosemeire; Campos, Orlando F.; De Andrade, José Lázaro; Carvalho, Antonio Carlos C.; Tucci, Paulo J.F.

In: Arquivos Brasileiros de Cardiologia, Vol. 75, No. 2, 01.01.2000, p. 131-136.

Research output: Contribution to journalArticle

Moisés, Valdir A. ; Ferreira, Ricardo L. ; Nozawa, Emília ; Takeuchi, Rosemeire ; Campos, Orlando F. ; De Andrade, José Lázaro ; Carvalho, Antonio Carlos C. ; Tucci, Paulo J.F. / Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography. In: Arquivos Brasileiros de Cardiologia. 2000 ; Vol. 75, No. 2. pp. 131-136.
@article{b1601654f0004b649c8357b28f274df7,
title = "Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography",
abstract = "Objective - To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. Methods - Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. Results - Echocardiography was 100{\%} sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5{\%} and signs of pulmonary hypertension straightening of pulmonary valve (90{\%}) and notching of pulmonary systolic flow (60{\%}) were observed in animals with extensive infarction. Conclusion - Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.",
keywords = "Doppler echocardiogram, Myocardial infarct, Rat hearts",
author = "Mois{\'e}s, {Valdir A.} and Ferreira, {Ricardo L.} and Em{\'i}lia Nozawa and Rosemeire Takeuchi and Campos, {Orlando F.} and {De Andrade}, {Jos{\'e} L{\'a}zaro} and Carvalho, {Antonio Carlos C.} and Tucci, {Paulo J.F.}",
year = "2000",
month = "1",
day = "1",
doi = "10.1590/S0066-782X2000000800005",
language = "English (US)",
volume = "75",
pages = "131--136",
journal = "Arquivos Brasileiros de Cardiologia",
issn = "0066-782X",
publisher = "Arquivos Brasileiros de Cardiologia",
number = "2",

}

TY - JOUR

T1 - Structural and functional characteristics of rat hearts with and without myocardial infarct. Initial experience with doppler echocardiography

AU - Moisés, Valdir A.

AU - Ferreira, Ricardo L.

AU - Nozawa, Emília

AU - Takeuchi, Rosemeire

AU - Campos, Orlando F.

AU - De Andrade, José Lázaro

AU - Carvalho, Antonio Carlos C.

AU - Tucci, Paulo J.F.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Objective - To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. Methods - Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. Results - Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. Conclusion - Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.

AB - Objective - To assess by Doppler echocardiography the structural and functional alterations of rat heart with surgical induced extensive myocardial infarction. Methods - Five weeks after surgical ligature of the left coronary artery, 38 Wistar-EPM rats of both sexes, 10 of them with extensive infarction, undergone anatomical and functional evaluation by Doppler echocardiography and then euthanized for anatomopathological analysis. Results - Echocardiography was 100% sensible and specific to anatomopathological confirmed extensive miocardial infarction. Extensive infarction lead to dilatation of left ventricle (diastolic diameter: 0.89cm vs.0.64cm; systolic: 0.72cm vs. 0.33cm) and left atrium (0.55cm vs. 0.33cm); thinning of left ventricular anterior wall (systolic: 0.14cm vs. 0.23cm, diastolic: 0.11cm vs. 0.14cm); increased mitral E/A wave relation (6.45 vs. 1.95). Signals of increased end diastolic ventricle pressure, B point in mitral valve tracing in 62.5% and signs of pulmonary hypertension straightening of pulmonary valve (90%) and notching of pulmonary systolic flow (60%) were observed in animals with extensive infarction. Conclusion - Doppler echocardiography has a high sensitivity and specificity for detection of chronic extensive infarction. Extensive infarction caused dilatation of left cardiac chambers and showed in Doppler signals of increased end diastolic left ventricular pressure and pulmonary artery pressure.

KW - Doppler echocardiogram

KW - Myocardial infarct

KW - Rat hearts

UR - http://www.scopus.com/inward/record.url?scp=85046528597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046528597&partnerID=8YFLogxK

U2 - 10.1590/S0066-782X2000000800005

DO - 10.1590/S0066-782X2000000800005

M3 - Article

VL - 75

SP - 131

EP - 136

JO - Arquivos Brasileiros de Cardiologia

JF - Arquivos Brasileiros de Cardiologia

SN - 0066-782X

IS - 2

ER -