Stroke recurrence within 2 years after ischemic infarction

D. B. Hier, M. A. Foulkes, M. Swiontoniowski, Ralph L Sacco, P. B. Gorelick, J. P. Mohr, T. R. Price, P. A. Wolf

Research output: Contribution to journalArticle

227 Scopus citations


We prospectively studied stroke recurrence in 1,273 patients with ischemic stroke who were entered into the Stroke Data Bank. Median follow-up was 13 months. The 2-year cumulative recurrence rate among these patients was 14.1%. Age, sex, race, history of hypertension, atrial fibrillation, or transient ischemic attacks, and stroke location were not associated with a higher risk of stroke recurrence. Patients with an elevated blood pressure, an abnormal initial computed tomogram, or a history of diabetes mellitus were at a higher risk of stroke recurrence. In contrast, patients with an infarct of unknown cause were at a lower risk of stroke recurrence than patients with a defined stroke mechanism, such as lacune, embolism, or atherosclerosis. A multivariate model suggests that patients at the lowest risk for stroke recurrence have a low diastolic blood pressure, no history of stroke, no history of diabetes mellitus, and an infarct of unknown cause.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
Issue number2
StatePublished - Feb 1 1991
Externally publishedYes



  • Cerebral infarction
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Hier, D. B., Foulkes, M. A., Swiontoniowski, M., Sacco, R. L., Gorelick, P. B., Mohr, J. P., Price, T. R., & Wolf, P. A. (1991). Stroke recurrence within 2 years after ischemic infarction. Stroke, 22(2), 155-161.