Abstract
Pediatric stroke research presents many challenges. Relatively low incidence, need for age stratification, diverse etiologies, delays in diagnosis, lack of an established age-based stroke severity scale and outcome measures are only some of the issues that have prevented the implementation of clinical trials in infants and children with stroke. Experimental animal models of pediatric stroke, therefore, are critical to understanding the pathophyslology and management of ischemic brain damage in the immature brain, and provide the necessary platform for future clinical trials. In this review we discuss the pertinent clinical aspects of pediatric stroke, the pathophysiology of stroke in the developing brain and the animal models established to study basic mechanisms as well as translational issues in pediatric.
| Original language | English |
|---|---|
| Pages (from-to) | 199-216 |
| Number of pages | 18 |
| Journal | Future Neurology |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2008 |
| Externally published | Yes |
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Keywords
- Brain ischemia
- Children
- Focal cerebral ischemia
- Pediatrics
- Stroke
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
Cite this
Stroke in the immature brain : Review of pathophysiology and animal models of pediatric stroke. / Kuluz, John; Huang, Tingting; Watson, Brant; Vannucci, Susan.
In: Future Neurology, Vol. 3, No. 2, 01.03.2008, p. 199-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stroke in the immature brain
T2 - Review of pathophysiology and animal models of pediatric stroke
AU - Kuluz, John
AU - Huang, Tingting
AU - Watson, Brant
AU - Vannucci, Susan
PY - 2008/3/1
Y1 - 2008/3/1
N2 - Pediatric stroke research presents many challenges. Relatively low incidence, need for age stratification, diverse etiologies, delays in diagnosis, lack of an established age-based stroke severity scale and outcome measures are only some of the issues that have prevented the implementation of clinical trials in infants and children with stroke. Experimental animal models of pediatric stroke, therefore, are critical to understanding the pathophyslology and management of ischemic brain damage in the immature brain, and provide the necessary platform for future clinical trials. In this review we discuss the pertinent clinical aspects of pediatric stroke, the pathophysiology of stroke in the developing brain and the animal models established to study basic mechanisms as well as translational issues in pediatric.
AB - Pediatric stroke research presents many challenges. Relatively low incidence, need for age stratification, diverse etiologies, delays in diagnosis, lack of an established age-based stroke severity scale and outcome measures are only some of the issues that have prevented the implementation of clinical trials in infants and children with stroke. Experimental animal models of pediatric stroke, therefore, are critical to understanding the pathophyslology and management of ischemic brain damage in the immature brain, and provide the necessary platform for future clinical trials. In this review we discuss the pertinent clinical aspects of pediatric stroke, the pathophysiology of stroke in the developing brain and the animal models established to study basic mechanisms as well as translational issues in pediatric.
KW - Brain ischemia
KW - Children
KW - Focal cerebral ischemia
KW - Pediatrics
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=40749108945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40749108945&partnerID=8YFLogxK
U2 - 10.2217/14796708.3.2.199
DO - 10.2217/14796708.3.2.199
M3 - Article
AN - SCOPUS:40749108945
VL - 3
SP - 199
EP - 216
JO - Future Neurology
JF - Future Neurology
SN - 1479-6708
IS - 2
ER -