Strict glycemic control and mortality risk among US adults with type 2 diabetes

Evelyn P. Davila; Hermes Florez; Mary Jo Trepka; Lora E. Fleming; Theophile Niyonsenga; David J. Lee; Jai Parkash

doi:10.1016/j.jdiacomp.2011.03.004

Strict glycemic control and mortality risk among US adults with type 2 diabetes

Evelyn P. Davila, Hermes Florez, Mary Jo Trepka, Lora E. Fleming, Theophile Niyonsenga, David J. Lee, Jai Parkash

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Objective: To assess the relationships between strict HbA1c levels and mortality risk among adults with type 2 diabetes by age, insulin therapy, and hypertension comorbidity. Methods: Data of adult participants with type 2 diabetes from the third National Health and Nutrition Examination Survey (1988-1994) and its linked mortality file (with follow-up death up to 2000) were used. Results: Having strict glycemic control (i.e., HbA1c ≤6.5%) was associated with a lower risk of mortality (hazards ratio=0.69; 95% confidence interval=0.48-0.98). However, among those with strict glycemic control levels, statistically significant results were not found. Conclusion: Reaching strict glycemic control levels in the general US population with type 2 diabetes appears to be associated with lower mortality. Further research is needed as to how strict glycemic control affects certain diabetic groups.

Original language	English (US)
Pages (from-to)	289-291
Number of pages	3
Journal	Journal of Diabetes and Its Complications
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.jdiacomp.2011.03.004
State	Published - Sep 2011

Keywords

Diabetes
Glycemic control
Mortality

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Internal Medicine

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title = "Strict glycemic control and mortality risk among US adults with type 2 diabetes",

abstract = "Objective: To assess the relationships between strict HbA1c levels and mortality risk among adults with type 2 diabetes by age, insulin therapy, and hypertension comorbidity. Methods: Data of adult participants with type 2 diabetes from the third National Health and Nutrition Examination Survey (1988-1994) and its linked mortality file (with follow-up death up to 2000) were used. Results: Having strict glycemic control (i.e., HbA1c ≤6.5%) was associated with a lower risk of mortality (hazards ratio=0.69; 95% confidence interval=0.48-0.98). However, among those with strict glycemic control levels, statistically significant results were not found. Conclusion: Reaching strict glycemic control levels in the general US population with type 2 diabetes appears to be associated with lower mortality. Further research is needed as to how strict glycemic control affects certain diabetic groups.",

keywords = "Diabetes, Glycemic control, Mortality",

author = "Davila, {Evelyn P.} and Hermes Florez and Trepka, {Mary Jo} and Fleming, {Lora E.} and Theophile Niyonsenga and Lee, {David J.} and Jai Parkash",

note = "Funding Information: This research was in part supported by the National Institute on Occupational Safety and Health (R01-0H03915). Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2011",

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doi = "10.1016/j.jdiacomp.2011.03.004",

language = "English (US)",

volume = "25",

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journal = "Journal of Diabetes and its Complications",

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AU - Davila, Evelyn P.

AU - Florez, Hermes

AU - Trepka, Mary Jo

AU - Fleming, Lora E.

AU - Niyonsenga, Theophile

AU - Lee, David J.

AU - Parkash, Jai

PY - 2011/9

Y1 - 2011/9

N2 - Objective: To assess the relationships between strict HbA1c levels and mortality risk among adults with type 2 diabetes by age, insulin therapy, and hypertension comorbidity. Methods: Data of adult participants with type 2 diabetes from the third National Health and Nutrition Examination Survey (1988-1994) and its linked mortality file (with follow-up death up to 2000) were used. Results: Having strict glycemic control (i.e., HbA1c ≤6.5%) was associated with a lower risk of mortality (hazards ratio=0.69; 95% confidence interval=0.48-0.98). However, among those with strict glycemic control levels, statistically significant results were not found. Conclusion: Reaching strict glycemic control levels in the general US population with type 2 diabetes appears to be associated with lower mortality. Further research is needed as to how strict glycemic control affects certain diabetic groups.

AB - Objective: To assess the relationships between strict HbA1c levels and mortality risk among adults with type 2 diabetes by age, insulin therapy, and hypertension comorbidity. Methods: Data of adult participants with type 2 diabetes from the third National Health and Nutrition Examination Survey (1988-1994) and its linked mortality file (with follow-up death up to 2000) were used. Results: Having strict glycemic control (i.e., HbA1c ≤6.5%) was associated with a lower risk of mortality (hazards ratio=0.69; 95% confidence interval=0.48-0.98). However, among those with strict glycemic control levels, statistically significant results were not found. Conclusion: Reaching strict glycemic control levels in the general US population with type 2 diabetes appears to be associated with lower mortality. Further research is needed as to how strict glycemic control affects certain diabetic groups.

KW - Diabetes

KW - Glycemic control

KW - Mortality

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Strict glycemic control and mortality risk among US adults with type 2 diabetes

Abstract

Keywords

ASJC Scopus subject areas

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