Striae distensae

Striae distensae are linear depressions in the skin that appear perpendicular to areas of increased skin tension. Striae are most commonly the result of changes in skin tension secondary to rapid fluctuations in weight and increases in muscle mass or height. They also appear frequently on the abdomen during pregnancy and in this context are referred to as striae gravidarum. Striae may also be the result of endogenous hypercortisolism like that seen in Cushing's syndrome or disease as well as exogenous hypercortisolism secondary to prolonged administration of systemic or topical corticosteroids. Regardless of the cause, clinically, striae appear initially as raised linear reddish/purple lesions that gradually progress to pale, wrinkled depressions in the skin. This chapter will address the pathophysiology and risks associated with the development of striae in the context of the above conditions as well as review preventive measures and known treatments. Finally, the chapter will conclude with a discussion on the future directions of the treatment of striae distensae and its subtypes.