Stressing the steroids in skin: Paradox or fine-tuning

Ivan Jozic, Olivera Stojadinovic, Robert S. Kirsner, Marjana Tomic-Canic

Research output: Contribution to journalComment/debate

16 Scopus citations

Abstract

The skin has recently been found to be an extra-Adrenal site for glucocorticoid (GC) synthesis that likely acts to modulate local inflammation. Psychological, physiological, and physical stress, both acute and chronic, triggers immune-protective or -damaging responses, including increases in systemic GC levels, which, according to Lin et al. (this issue), may be beneficial in inflammatory skin disease. However, little is known about the interplay between local and systemic production of GCs and the effect of stress (local or systemic) in regulating tissue-specific GC synthesis, its impact on skin homeostasis, and its effect of skin disease.

Original languageEnglish (US)
Pages (from-to)2869-2872
Number of pages4
JournalJournal of Investigative Dermatology
Volume134
Issue number12
DOIs
StatePublished - Dec 13 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Fingerprint Dive into the research topics of 'Stressing the steroids in skin: Paradox or fine-tuning'. Together they form a unique fingerprint.

  • Cite this