Stressing the steroids in skin

Paradox or fine-tuning

Ivan Jozic, Olivera Stojadinovic, Robert Kirsner, Marjana Tomic-Canic

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The skin has recently been found to be an extra-Adrenal site for glucocorticoid (GC) synthesis that likely acts to modulate local inflammation. Psychological, physiological, and physical stress, both acute and chronic, triggers immune-protective or -damaging responses, including increases in systemic GC levels, which, according to Lin et al. (this issue), may be beneficial in inflammatory skin disease. However, little is known about the interplay between local and systemic production of GCs and the effect of stress (local or systemic) in regulating tissue-specific GC synthesis, its impact on skin homeostasis, and its effect of skin disease.

Original languageEnglish
Pages (from-to)2869-2872
Number of pages4
JournalJournal of Investigative Dermatology
Volume134
Issue number12
DOIs
StatePublished - Jan 1 2014

Fingerprint

Glucocorticoids
Skin
Tuning
Steroids
Skin Diseases
Homeostasis
Psychology
Inflammation
Tissue

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Stressing the steroids in skin : Paradox or fine-tuning. / Jozic, Ivan; Stojadinovic, Olivera; Kirsner, Robert; Tomic-Canic, Marjana.

In: Journal of Investigative Dermatology, Vol. 134, No. 12, 01.01.2014, p. 2869-2872.

Research output: Contribution to journalArticle

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